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Literature summary extracted from

  • Gregus, Z.; Nemeti, B.
    The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol (2005), Toxicol. Sci., 5, 859-869.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.12 ADP moderately inhibits arsenate reductase activity Homo sapiens
1.2.1.12 ADP moderately inhibits arsenate reductase activity Rattus norvegicus
1.2.1.12 ATP moderately inhibits arsenate reductase activity Homo sapiens
1.2.1.12 ATP moderately inhibits arsenate reductase activity Rattus norvegicus
1.2.1.12 Koningic acid inhibits arsenate reductase activity and activity with D-glyceraldehyde 3-phosphate, phosphate and NAD+ Homo sapiens
1.2.1.12 Koningic acid inhibits arsenate reductase activity and activity with D-glyceraldehyde 3-phosphate, phosphate and NAD+ Rattus norvegicus
1.2.1.12 NADH strongly inhibits arsenate reductase activity Homo sapiens
1.2.1.12 NADH strongly inhibits arsenate reductase activity Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.12 cytosol
-
 Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.12 Homo sapiens
-
-
-
1.2.1.12 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.12 erythrocyte
-
 Homo sapiens
-
1.2.1.12 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.12 arsenate + GSH + NAD+ + glyceraldehyde 3-phosphate
-
 Homo sapiens arsenite + ?
-
 ?
1.2.1.12 arsenate + GSH + NAD+ + glyceraldehyde 3-phosphate
-
 Rattus norvegicus arsenite + ?
-
 ?