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Literature summary extracted from

  • Sotriffer, C.A.; Kramer, O.; Klebe, G.
    Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations (2004), Proteins, 56, 52-66.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.21 C298A/W219Y protein data bank: 1az1, structural analysis by molecular dynamics simulations Homo sapiens
1.1.1.21 Y48H protein data bank: 2acu, structural analysis by molecular dynamics simulations Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 IDD594
-
 Homo sapiens
1.1.1.21 IDD594
-
 Sus scrofa
1.1.1.21 sorbinil
-
 Homo sapiens
1.1.1.21 sorbinil
-
 Sus scrofa
1.1.1.21 Tolrestat
-
 Homo sapiens
1.1.1.21 Tolrestat
-
 Sus scrofa
1.1.1.21 Zenarestat
-
 Homo sapiens
1.1.1.21 Zenarestat
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-
1.1.1.21 Sus scrofa
-
-
-

Subunits

EC Number Subunits Comment Organism
1.1.1.21 More structural analysis by molecular dynamics simulations, highly conserved confomations around the catalytic site with H110-Y48-NADP+ orientation stabilized by a water molecule Homo sapiens
1.1.1.21 More structural analysis by molecular dynamics simulations, highly conserved confomations around the catalytic site with H110-Y48-NADP+ orientation stabilized by a water molecule Sus scrofa