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Literature summary extracted from

  • Musayev, F.N.; Di Salvo, M.L.; Ko, T.P.; Schirch, V.; Safo, M.K.
    Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase (2003), Protein Sci., 12, 1455-1463.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.3.5 hanging-drop and sitting-drop method, crystallized without and with an excess of pyridoxal 5'-phosphate. Structures are determined to 1.95 A and 2.65 A, respectively Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.5 pyridoxal 5'-phosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.5 1
-
 pyridoxamine 5'-phosphate pH 7.6, 37°C Homo sapiens
1.4.3.5 1.8
-
 pyridoxine 5'-phosphate pH 7.6, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.5 pyridoxamine 5'-phosphate + H2O + O2 Homo sapiens terminal step in de novo biosynthesis of pyridoxal 5'-phosphate pyridoxal 5'-phosphate + NH3 + H2O2
-
 ?
1.4.3.5 pyridoxine 5'-phosphate + H2O + O2 Homo sapiens terminal step in de novo biosynthesis of pyridoxal 5'-phosphate pyridoxal 5'-phosphate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.5
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.5 pyridoxamine 5'-phosphate + H2O + O2
-
 Homo sapiens pyridoxal 5'-phosphate + NH3 + H2O2
-
 ?
1.4.3.5 pyridoxamine 5'-phosphate + H2O + O2 terminal step in de novo biosynthesis of pyridoxal 5'-phosphate Homo sapiens pyridoxal 5'-phosphate + NH3 + H2O2
-
 ?
1.4.3.5 pyridoxine 5'-phosphate + H2O + O2
-
 Homo sapiens pyridoxal 5'-phosphate + H2O2
-
 ?
1.4.3.5 pyridoxine 5'-phosphate + H2O + O2 terminal step in de novo biosynthesis of pyridoxal 5'-phosphate Homo sapiens pyridoxal 5'-phosphate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.5 pyridoxine 5'-phosphate oxidase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.5 0.19
-
 pyridoxine 5'-phosphate pH 7.6, 37°C Homo sapiens
1.4.3.5 0.2
-
 pyridoxamine 5'-phosphate pH 7.6, 37°C Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.5 0.0032
-
 pyridoxal 5'-phosphate pH 7.6, 37°C Homo sapiens