BRENDA - Enzyme Database show

Prostaglandin F synthase

Watanabe, K.; Prostaglandins 68-69, 401-407 (2002)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.1.1.188
GSH
dependent on
Ovis aries
1.1.1.188
additional information
4fold activation by heat treatment
Ovis aries
Engineering
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.188
Y55F
complete elimination of PGD2, and PQ reductase activities, 27fold stimulation of PGH2 reductase activity
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.188
9,10-phenanthrenequinone
competitive inhibition of the PGD2 11-ketoreductase activity, not of PGH2 9-,11-endoperoxide reductase activity
Rattus norvegicus
1.1.1.188
additional information
no inhibition by 9,10-phenanthrenequinone
Trypanosoma brucei
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.188
cytosol
-
Bos taurus
5829
-
1.1.1.188
cytosol
-
Homo sapiens
5829
-
1.1.1.188
cytosol
-
Oryctolagus cuniculus
5829
-
1.1.1.188
cytosol
-
Rattus norvegicus
5829
-
1.1.1.188
cytosol
-
Trypanosoma brucei
5829
-
1.1.1.188
membrane
associated
Ovis aries
16020
-
1.1.1.188
microsome
-
Ovis aries
-
-
1.1.1.189
cytosol
-
Bos taurus
5829
-
1.1.1.189
cytosol
-
Gallus gallus
5829
-
1.1.1.189
cytosol
-
Homo sapiens
5829
-
1.1.1.189
cytosol
-
Oryctolagus cuniculus
5829
-
1.1.1.189
cytosol
-
Sus scrofa
5829
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.1.1.188
16000
-
1 * 16000
Ovis aries
1.1.1.188
17000
-
-
Ovis aries
1.1.1.188
33000
-
-
Trypanosoma brucei
1.1.1.188
36666
-
1 * 36666, lung enzyme, sequence calculation
Rattus norvegicus
1.1.1.188
36670
-
lung enzyme, sequence calculation
Rattus norvegicus
1.1.1.188
37000
-
lung and liver isozymes
Bos taurus
1.1.1.188
37000
-
lung isozyme
Homo sapiens
1.1.1.189
36000
-
-
Homo sapiens
1.1.1.189
37000
-
-
Oryctolagus cuniculus
1.1.1.189
45000
-
-
Bos taurus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.188
prostaglandin D2 + NADPH + H+
Homo sapiens
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
Rattus norvegicus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
Bos taurus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
Oryctolagus cuniculus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
1.1.1.188
prostaglandin H2 + NADPH
Homo sapiens
-
prostaglandin D2 + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Rattus norvegicus
-
prostaglandin D2 + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Bos taurus
-
prostaglandin D2 + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Oryctolagus cuniculus
-
prostaglandin D2 + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Ovis aries
-
prostaglandin F2alpha + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Trypanosoma brucei
-
prostaglandin F2alpha + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Bos taurus
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
prostaglandin F2alpha + NADP+
-
-
?
1.1.1.189
prostaglandin H2 + NAD(P)H
Gallus gallus
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Homo sapiens
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Sus scrofa
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Bos taurus
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Oryctolagus cuniculus
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Gallus gallus
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Homo sapiens
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Sus scrofa
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Bos taurus
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Oryctolagus cuniculus
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.188
Bos taurus
-
to isozymes in lung and liver
-
1.1.1.188
Homo sapiens
-
-
-
1.1.1.188
Oryctolagus cuniculus
-
-
-
1.1.1.188
Ovis aries
-
-
-
1.1.1.188
Rattus norvegicus
-
two isozymes in lung and liver
-
1.1.1.188
Trypanosoma brucei
-
-
-
1.1.1.189
Bos taurus
-
-
-
1.1.1.189
Gallus gallus
-
-
-
1.1.1.189
Homo sapiens
-
-
-
1.1.1.189
Oryctolagus cuniculus
-
-
-
1.1.1.189
Sus scrofa
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.1.1.188
enzyme from lung, to homogeneity
Rattus norvegicus
Reaction
EC Number
Reaction
Commentary
Organism
1.1.1.188
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
Tyr55 is critical for the reaction, the reactions with different substrates might follow different mechanisms
Rattus norvegicus
1.1.1.189
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
human carbonyl reductase and 20alpha-hydroxysteroid dehydrogenase are identical with the PGE2 9-ketoreductase
Homo sapiens
1.1.1.189
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
enzyme is identical to carbonyl reductase
Sus scrofa
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.188
liver
-
Bos taurus
-
1.1.1.188
liver
liver-type isozyme
Oryctolagus cuniculus
-
1.1.1.188
liver
-
Rattus norvegicus
-
1.1.1.188
lung
; PGH2 9-,11-endoperoxide reductase activity lung-type isozyme
Bos taurus
-
1.1.1.188
lung
lung-type isozyme
Homo sapiens
-
1.1.1.188
lung
-
Rattus norvegicus
-
1.1.1.188
seminal vesicle
-
Ovis aries
-
1.1.1.189
brain
-
Homo sapiens
-
1.1.1.189
corpus luteum
-
Oryctolagus cuniculus
-
1.1.1.189
heart
-
Gallus gallus
-
1.1.1.189
kidney
-
Homo sapiens
-
1.1.1.189
kidney
-
Sus scrofa
-
1.1.1.189
placenta
-
Bos taurus
-
1.1.1.189
placenta
-
Homo sapiens
-
1.1.1.189
uterine endometrium
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.188
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Homo sapiens
?
-
-
-
?
1.1.1.188
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Rattus norvegicus
?
-
-
-
?
1.1.1.188
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Bos taurus
?
-
-
-
?
1.1.1.188
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Oryctolagus cuniculus
?
-
-
-
?
1.1.1.188
additional information
enzyme does not reduce prostaglandins D2 and E2
657211
Trypanosoma brucei
?
-
-
-
-
1.1.1.188
additional information
enzyme shows no prostaglandin D2 11-ketoreductase activity, and no glutathione S-transferase activity, although it is similar to the glutathione S-transferase
657211
Ovis aries
?
-
-
-
-
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Homo sapiens
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Rattus norvegicus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Bos taurus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Oryctolagus cuniculus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Homo sapiens
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Rattus norvegicus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Bos taurus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Oryctolagus cuniculus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Homo sapiens
prostaglandin D2 + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Rattus norvegicus
prostaglandin D2 + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Bos taurus
prostaglandin D2 + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Oryctolagus cuniculus
prostaglandin D2 + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Ovis aries
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Trypanosoma brucei
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Trypanosoma brucei
prostaglandin F2alpha + NADP+
no stereochemic determination/identification of the product
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Homo sapiens
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Rattus norvegicus
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Bos taurus
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Oryctolagus cuniculus
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.189
additional information
broad substrate specificity, enzyme shows 15-hydroxy dehydrogenase activity in presence of NADP+ or NAD+
657211
Gallus gallus
?
-
-
-
-
1.1.1.189
additional information
broad substrate specificity, enzyme shows 15-hydroxy dehydrogenase activity in presence of NADP+ or NAD+
657211
Homo sapiens
?
-
-
-
-
1.1.1.189
additional information
broad substrate specificity, enzyme shows 15-hydroxy dehydrogenase activity in presence of NADP+ or NAD+
657211
Sus scrofa
?
-
-
-
-
1.1.1.189
additional information
broad substrate specificity, enzyme shows 15-hydroxy dehydrogenase activity in presence of NADP+ or NAD+
657211
Oryctolagus cuniculus
?
-
-
-
-
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Gallus gallus
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Homo sapiens
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Sus scrofa
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Bos taurus
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Oryctolagus cuniculus
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Gallus gallus
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Homo sapiens
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Sus scrofa
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Bos taurus
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Oryctolagus cuniculus
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Gallus gallus
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Homo sapiens
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Sus scrofa
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Bos taurus
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Oryctolagus cuniculus
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
Subunits
EC Number
Subunits
Commentary
Organism
1.1.1.188
monomer
1 * 16000
Ovis aries
1.1.1.188
monomer
1 * 36666, lung enzyme, sequence calculation
Rattus norvegicus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.188
NADPH
dependent on
Bos taurus
1.1.1.188
NADPH
dependent on
Oryctolagus cuniculus
1.1.1.188
NADPH
dependent on
Ovis aries
1.1.1.188
NADPH
dependent on
Rattus norvegicus
1.1.1.188
NADPH
dependent on
Trypanosoma brucei
1.1.1.189
NAD+
-
Bos taurus
1.1.1.189
NAD+
-
Gallus gallus
1.1.1.189
NAD+
-
Homo sapiens
1.1.1.189
NAD+
-
Oryctolagus cuniculus
1.1.1.189
NAD+
-
Sus scrofa
1.1.1.189
NADH
-
Bos taurus
1.1.1.189
NADH
-
Gallus gallus
1.1.1.189
NADH
-
Homo sapiens
1.1.1.189
NADH
-
Oryctolagus cuniculus
1.1.1.189
NADH
-
Sus scrofa
1.1.1.189
NADP+
-
Gallus gallus
1.1.1.189
NADP+
-
Homo sapiens
1.1.1.189
NADP+
-
Oryctolagus cuniculus
1.1.1.189
NADP+
-
Sus scrofa
1.1.1.189
NADP+
-
Bos taurus
1.1.1.189
NADPH
-
Gallus gallus
1.1.1.189
NADPH
-
Oryctolagus cuniculus
1.1.1.189
NADPH
-
Sus scrofa
1.1.1.189
NADPH
-
Bos taurus
1.1.1.189
NADPH
-
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.1.1.188
GSH
dependent on
Ovis aries
1.1.1.188
additional information
4fold activation by heat treatment
Ovis aries
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.188
NADPH
dependent on
Bos taurus
1.1.1.188
NADPH
dependent on
Oryctolagus cuniculus
1.1.1.188
NADPH
dependent on
Ovis aries
1.1.1.188
NADPH
dependent on
Rattus norvegicus
1.1.1.188
NADPH
dependent on
Trypanosoma brucei
1.1.1.189
NAD+
-
Bos taurus
1.1.1.189
NAD+
-
Gallus gallus
1.1.1.189
NAD+
-
Homo sapiens
1.1.1.189
NAD+
-
Oryctolagus cuniculus
1.1.1.189
NAD+
-
Sus scrofa
1.1.1.189
NADH
-
Bos taurus
1.1.1.189
NADH
-
Gallus gallus
1.1.1.189
NADH
-
Homo sapiens
1.1.1.189
NADH
-
Oryctolagus cuniculus
1.1.1.189
NADH
-
Sus scrofa
1.1.1.189
NADP+
-
Gallus gallus
1.1.1.189
NADP+
-
Homo sapiens
1.1.1.189
NADP+
-
Oryctolagus cuniculus
1.1.1.189
NADP+
-
Sus scrofa
1.1.1.189
NADP+
-
Bos taurus
1.1.1.189
NADPH
-
Gallus gallus
1.1.1.189
NADPH
-
Oryctolagus cuniculus
1.1.1.189
NADPH
-
Sus scrofa
1.1.1.189
NADPH
-
Bos taurus
1.1.1.189
NADPH
-
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.188
Y55F
complete elimination of PGD2, and PQ reductase activities, 27fold stimulation of PGH2 reductase activity
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.188
9,10-phenanthrenequinone
competitive inhibition of the PGD2 11-ketoreductase activity, not of PGH2 9-,11-endoperoxide reductase activity
Rattus norvegicus
1.1.1.188
additional information
no inhibition by 9,10-phenanthrenequinone
Trypanosoma brucei
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.188
cytosol
-
Bos taurus
5829
-
1.1.1.188
cytosol
-
Homo sapiens
5829
-
1.1.1.188
cytosol
-
Oryctolagus cuniculus
5829
-
1.1.1.188
cytosol
-
Rattus norvegicus
5829
-
1.1.1.188
cytosol
-
Trypanosoma brucei
5829
-
1.1.1.188
membrane
associated
Ovis aries
16020
-
1.1.1.188
microsome
-
Ovis aries
-
-
1.1.1.189
cytosol
-
Bos taurus
5829
-
1.1.1.189
cytosol
-
Gallus gallus
5829
-
1.1.1.189
cytosol
-
Homo sapiens
5829
-
1.1.1.189
cytosol
-
Oryctolagus cuniculus
5829
-
1.1.1.189
cytosol
-
Sus scrofa
5829
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.1.1.188
16000
-
1 * 16000
Ovis aries
1.1.1.188
17000
-
-
Ovis aries
1.1.1.188
33000
-
-
Trypanosoma brucei
1.1.1.188
36666
-
1 * 36666, lung enzyme, sequence calculation
Rattus norvegicus
1.1.1.188
36670
-
lung enzyme, sequence calculation
Rattus norvegicus
1.1.1.188
37000
-
lung and liver isozymes
Bos taurus
1.1.1.188
37000
-
lung isozyme
Homo sapiens
1.1.1.189
36000
-
-
Homo sapiens
1.1.1.189
37000
-
-
Oryctolagus cuniculus
1.1.1.189
45000
-
-
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.188
prostaglandin D2 + NADPH + H+
Homo sapiens
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
Rattus norvegicus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
Bos taurus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
Oryctolagus cuniculus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
1.1.1.188
prostaglandin H2 + NADPH
Homo sapiens
-
prostaglandin D2 + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Rattus norvegicus
-
prostaglandin D2 + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Bos taurus
-
prostaglandin D2 + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Oryctolagus cuniculus
-
prostaglandin D2 + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Ovis aries
-
prostaglandin F2alpha + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Trypanosoma brucei
-
prostaglandin F2alpha + NADP+
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
Bos taurus
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
prostaglandin F2alpha + NADP+
-
-
?
1.1.1.189
prostaglandin H2 + NAD(P)H
Gallus gallus
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Homo sapiens
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Sus scrofa
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Bos taurus
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Oryctolagus cuniculus
-
prostaglandin E2 + NAD(P)+
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Gallus gallus
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Homo sapiens
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Sus scrofa
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Bos taurus
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
Oryctolagus cuniculus
-
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
r
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.188
enzyme from lung, to homogeneity
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.188
liver
-
Bos taurus
-
1.1.1.188
liver
liver-type isozyme
Oryctolagus cuniculus
-
1.1.1.188
liver
-
Rattus norvegicus
-
1.1.1.188
lung
; PGH2 9-,11-endoperoxide reductase activity lung-type isozyme
Bos taurus
-
1.1.1.188
lung
lung-type isozyme
Homo sapiens
-
1.1.1.188
lung
-
Rattus norvegicus
-
1.1.1.188
seminal vesicle
-
Ovis aries
-
1.1.1.189
brain
-
Homo sapiens
-
1.1.1.189
corpus luteum
-
Oryctolagus cuniculus
-
1.1.1.189
heart
-
Gallus gallus
-
1.1.1.189
kidney
-
Homo sapiens
-
1.1.1.189
kidney
-
Sus scrofa
-
1.1.1.189
placenta
-
Bos taurus
-
1.1.1.189
placenta
-
Homo sapiens
-
1.1.1.189
uterine endometrium
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.188
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Homo sapiens
?
-
-
-
?
1.1.1.188
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Rattus norvegicus
?
-
-
-
?
1.1.1.188
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Bos taurus
?
-
-
-
?
1.1.1.188
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Oryctolagus cuniculus
?
-
-
-
?
1.1.1.188
additional information
enzyme does not reduce prostaglandins D2 and E2
657211
Trypanosoma brucei
?
-
-
-
-
1.1.1.188
additional information
enzyme shows no prostaglandin D2 11-ketoreductase activity, and no glutathione S-transferase activity, although it is similar to the glutathione S-transferase
657211
Ovis aries
?
-
-
-
-
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Homo sapiens
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Rattus norvegicus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Bos taurus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Oryctolagus cuniculus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Homo sapiens
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Rattus norvegicus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Bos taurus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
1.1.1.188
prostaglandin D2 + NADPH + H+
-
657211
Oryctolagus cuniculus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Homo sapiens
prostaglandin D2 + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Rattus norvegicus
prostaglandin D2 + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Bos taurus
prostaglandin D2 + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Oryctolagus cuniculus
prostaglandin D2 + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Ovis aries
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Trypanosoma brucei
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
-
657211
Trypanosoma brucei
prostaglandin F2alpha + NADP+
no stereochemic determination/identification of the product
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Homo sapiens
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Rattus norvegicus
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Bos taurus
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.188
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Oryctolagus cuniculus
prostaglandin F2alpha + NADP+
-
-
-
?
1.1.1.189
additional information
broad substrate specificity, enzyme shows 15-hydroxy dehydrogenase activity in presence of NADP+ or NAD+
657211
Gallus gallus
?
-
-
-
-
1.1.1.189
additional information
broad substrate specificity, enzyme shows 15-hydroxy dehydrogenase activity in presence of NADP+ or NAD+
657211
Homo sapiens
?
-
-
-
-
1.1.1.189
additional information
broad substrate specificity, enzyme shows 15-hydroxy dehydrogenase activity in presence of NADP+ or NAD+
657211
Sus scrofa
?
-
-
-
-
1.1.1.189
additional information
broad substrate specificity, enzyme shows 15-hydroxy dehydrogenase activity in presence of NADP+ or NAD+
657211
Oryctolagus cuniculus
?
-
-
-
-
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Gallus gallus
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Homo sapiens
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Sus scrofa
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Bos taurus
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin E2 + NAD(P)H
-
657211
Oryctolagus cuniculus
prostaglandin F2alpha + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Gallus gallus
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Homo sapiens
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Sus scrofa
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Bos taurus
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Oryctolagus cuniculus
prostaglandin E2 + NAD(P)+
-
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Gallus gallus
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Homo sapiens
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Sus scrofa
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Bos taurus
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
1.1.1.189
prostaglandin H2 + NAD(P)H
-
657211
Oryctolagus cuniculus
prostaglandin F2alpha + NAD(P)+
product is involved in bronchial, vascular, and arterial smooth muscle contraction
-
-
r
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
1.1.1.188
monomer
1 * 16000
Ovis aries
1.1.1.188
monomer
1 * 36666, lung enzyme, sequence calculation
Rattus norvegicus