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Literature summary extracted from

  • Suzuki, M.; Kamide, Y.; Nagata, N.; Seki, H.; Ohyama, K.; Kato, H.; Masuda, K.; Sato, S.; Kato, T.; Tabata, S.; Yoshida, S.; Muranaka, T.
    Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels (2004), Plant J., 37, 750-761.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.34 additional information construction of insertion mutants of the 2 isozymes leads to loss of enzyme function, the hmg1 mutant plants show an altered phenotype with dwarfing, early senescence, male sterility, and both mutants of hmg1 and hmg2 show reduced sterol levels, the mutants are more sensitive to the inhibitor lovastatin and squalestatin, overview Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 lovastatin
-
 Arabidopsis thaliana
1.1.1.34 squalestatin mutant plants, not wild-type plants, become sterile Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Arabidopsis thaliana enzyme is essential for sterol biosynthesis (R)-mevalonate + CoA + 2 NADP+
-
 r
1.1.1.34 additional information Arabidopsis thaliana phytosterol biosynthetic pathway, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Arabidopsis thaliana
-
 2 genes hmg1 and hmg2 encode 2 isozymes HMG1 and HMG2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Arabidopsis thaliana (R)-mevalonate + CoA + 2 NADP+
-
 r
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ enzyme is essential for sterol biosynthesis Arabidopsis thaliana (R)-mevalonate + CoA + 2 NADP+
-
 r
1.1.1.34 additional information phytosterol biosynthetic pathway, overview Arabidopsis thaliana ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1
-
 Arabidopsis thaliana
1.1.1.34 HMG1
-
 Arabidopsis thaliana
1.1.1.34 HMG2
-
 Arabidopsis thaliana
1.1.1.34 HMGR
-
 Arabidopsis thaliana