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Literature summary extracted from

  • Czerniecki, J.; Chanas, G.; Verlaet, M.; Bettendorff, L.; Makarchikov, A.F.; Leprince, P.; Wins, P.; Grisar, T.; Lakaye, B.
    Neuronal localization of the 25-kDa specific thiamine triphosphatase in rodent brain (2004), Neuroscience, 125, 833-840.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.28 cytoplasm of neuronal perkarya Rattus norvegicus 5737
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.28 thiamine triphosphate + H2O Rattus norvegicus the enzyme may play a general role in neuronal metabolism rather than a specific role in excitability. There is no apparent correlation between enzyme expression and selective vulnerability of certain brain regions to thiamine deficiency thiamine diphosphate + phosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.28 Rattus norvegicus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.28 brain highest activity in hippocampal pyramidal neurons, as well as cerbellar granule cells and Purkinje cells. Some interneurons are also labeled and many thiamine triphosphatase mRNA-positive and immunoreactive cells are distributed thoughout cerebral cortical gray matter and the thalamus. No significant activity in white matter Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.28 thiamine triphosphate + H2O
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 Rattus norvegicus thiamine diphosphate + phosphate
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 ?
3.6.1.28 thiamine triphosphate + H2O the enzyme may play a general role in neuronal metabolism rather than a specific role in excitability. There is no apparent correlation between enzyme expression and selective vulnerability of certain brain regions to thiamine deficiency Rattus norvegicus thiamine diphosphate + phosphate
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.28 ThTPase
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 Rattus norvegicus