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Literature summary extracted from

  • Cheng, L.Y.; Wang, J.Z.; Gong, C.X.; Pei, J.J.; Zaidi, T.; Grundke-Iqbal, I.; Iqbal, K.
    Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue nonbinding phosphatase activities (2001), Neurochem. Res., 26, 425-438.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 calyculin moderate inhibition at 0.00001 mM Homo sapiens
3.1.3.16 cantheridin strong inhibition at 0.005 mM Homo sapiens
3.1.3.16 EGTA moderate inhibition Homo sapiens
3.1.3.16 NaF moderate inhibition; strong inhibition Homo sapiens
3.1.3.16 Tartrate moderate inhibition of P11 at 2 mM; strong inhibition Homo sapiens
3.1.3.16 tetramisole strong inhibition at 2 mM Homo sapiens
3.1.3.16 Trifluorperazine moderate inhibition; strong inhibition; strong inhibition at 0.1 mM Homo sapiens
3.1.3.16 vanadate at 1 mM inhibition to 60% of its activity Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.16 Ca2+
-
 Homo sapiens
3.1.3.16 Co2+
-
 Homo sapiens
3.1.3.16 Mg2+
-
 Homo sapiens
3.1.3.16 Mg2+ better activator than Mn2+ Homo sapiens
3.1.3.16 Mn2+
-
 Homo sapiens
3.1.3.16 Mn2+ better activator than Mg2+ Homo sapiens
3.1.3.16 Ni2+
-
 Homo sapiens
3.1.3.16 Ni2+ best activator Homo sapiens
3.1.3.16 Ni2+ best activator for P5 Homo sapiens
3.1.3.16 Zn2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.16 32000
-
 gel filtration Homo sapiens
3.1.3.16 49000
-
 gel filtration Homo sapiens
3.1.3.16 90000
-
 gel filtration Homo sapiens
3.1.3.16 150000
-
 gel filtration Homo sapiens
3.1.3.16 165000
-
 gel filtration Homo sapiens
3.1.3.16 250000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.16
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.16 0.5
-
 with phosphorylase kinase as substrate Homo sapiens
3.1.3.16 2
-
 with phosphorylase kinase as substrate Homo sapiens
3.1.3.16 3
-
 with phosphorylase kinase as substrate Homo sapiens
3.1.3.16 3 8 with p-nitrophenylphosphate as substrate Homo sapiens
3.1.3.16 4
-
 with phosphorylase kinase as substrate Homo sapiens
3.1.3.16 8
-
 with phosphorylase kinase as substrate Homo sapiens
3.1.3.16 11
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
3.1.3.16 14
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
3.1.3.16 16
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
3.1.3.16 19
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
3.1.3.16 40
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
3.1.3.16 310
-
 with p-nitrophenyl phosphate as substrate Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 p-nitrophenyl phosphate + H2O
-
 Homo sapiens p-nitrophenol + phosphate
-
 ?
3.1.3.16 phosphorylated AD P-Tau + H2O
-
 Homo sapiens AD P-Tau + phosphate
-
 ?
3.1.3.16 phosphorylated phosphorylase kinase + H2O
-
 Homo sapiens phosphorylase kinase + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 P10
-
 Homo sapiens
3.1.3.16 P11
-
 Homo sapiens
3.1.3.16 P5
-
 Homo sapiens
3.1.3.16 P6
-
 Homo sapiens
3.1.3.16 P7
-
 Homo sapiens
3.1.3.16 P8
-
 Homo sapiens
3.1.3.16 P9
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.16 additional information
-
 biphasic pH-optimum at pH 7.5 and 8.5 with Mn2+ as activator Homo sapiens
3.1.3.16 7
-
 with Mg2+ as activator Homo sapiens
3.1.3.16 7.5
-
 with Mn2+ as activator Homo sapiens
3.1.3.16 7.5 8.5 with Mn2+ as activator Homo sapiens
3.1.3.16 7.5 8 with Mg2+ as activator Homo sapiens
3.1.3.16 8.5
-
 with Mg2+ as activator Homo sapiens
3.1.3.16 8.5
-
 with Mn2+ as activator Homo sapiens
3.1.3.16 10
-
 with Mg2+ as activator Homo sapiens