Literature summary extracted from

diFabio, J.; Ji, Y.; Vasiliou, V.; Thatcher, G.R.; Bennett, B.M.
Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance (2003), Mol. Pharmacol., 64, 1109-1116.

Application

EC Number	Application	Comment	Organism
1.2.1.3	medicine	glyceryl trinitrate is used in the treatment of angina pectoris and cardiac failure, but the rapid onset of glyceryl trinitrate tolerance limits its clinical utility.The majority of the vascular ALDH2 is present in the cytoplasm, suggesting that mitochondrial biotransformation of glyceryl trinitrate by ALDH2 plays a minor role in the overall vascular biotransformation	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.2.1.3	mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.2.1.3	additional information	Rattus norvegicus	the majority of the vascular ALDH2 is present in the cytoplasm, suggesting that mitochondrial biotransformation of glyceryl trinitrate by ALDH2 plays a minor role in the overall vascular biotransformation	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.2.1.3	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.2.1.3	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.2.1.3	additional information	the majority of the vascular ALDH2 is present in the cytoplasm, suggesting that mitochondrial biotransformation of glyceryl trinitrate by ALDH2 plays a minor role in the overall vascular biotransformation	Rattus norvegicus	?	-	?
1.2.1.3	propanal + NAD+ + H2O	-	Rattus norvegicus	propionate + NADH	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.2.1.3	ALDH2	-	Rattus norvegicus

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Release 2023.1 (January 2023)