Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sharma, N.; Okere, I.C.; Brunengraber, D.Z.; McElfresh, T.A.; King, K.L.; Sterk, J.P.; Huang, H.; Chandler, M.P.; Stanley, W.C.
    Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation (2005), J. Physiol., 562, 593-603.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.104 dobutamine increases pyruvate dehydrogenase complex activity Sus scrofa
1.2.1.104 additional information enzyme complex activity is increased with high workload and energy expenditure in the myocardium Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.104 mitochondrion
-
 Sus scrofa 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.104 additional information Sus scrofa regulation of pyruvate dehydrogenase complex activity and citric acid cycle intermediates during high cardiac power generation, inhibition of fatty acid oxidation has a regulatory function, overview ?
-
 ?
1.2.1.104 pyruvate + CoA + NAD+ Sus scrofa
-
 acetyl-CoA + CO2 + NADH
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.2.1.104 phosphoprotein regulation of pyruvate dehydrogenase complex activity through reversible phosphorylation Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.104 heart
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.104 additional information
-
 measurement of NADH/NAD+ and acetyl-CoA/CoA ratios, and citric acid cycle intermediates in blood and tissue, measurement of O2-uptake and fatty acid and glucose oxidation level Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 additional information regulation of pyruvate dehydrogenase complex activity and citric acid cycle intermediates during high cardiac power generation, inhibition of fatty acid oxidation has a regulatory function, overview Sus scrofa ?
-
 ?
1.2.1.104 pyruvate + CoA + NAD+
-
 Sus scrofa acetyl-CoA + CO2 + NADH
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.2.1.104 PDH
-
 Sus scrofa
1.2.1.104 pyruvate dehydrogenase complex
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 NAD+
-
 Sus scrofa