EC Number | Application | Comment | Organism |
---|---|---|---|
1.2.1.105 | medicine | hypochlorous acid and chloramines have the potential to inactivate KGDHC, a major target in neurodegeneration | Sus scrofa |
1.2.1.105 | medicine | hypochlorous acid and chloramines have the potential to inactivate KGDHC, a major target in neurodegeneration, without significant loss of cellular viability | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.105 | H2O2 | inhibits lysate KGDHC in a concentration- and time-dependent manner, inhibitory effect reversed by addition of dithiothreitol | Mus musculus | |
1.2.1.105 | H2O2 | ca. 300 times less effective than mono-N-chloramine | Sus scrofa | |
1.2.1.105 | hypochlorous acid | myeloperoxidase product, inhibition of the alpha-ketoglutarate dehydrogenase multienzyme complex in vivo | Homo sapiens | |
1.2.1.105 | hypochlorous acid | concentration-dependent monophasic inhibition | Mus musculus | |
1.2.1.105 | hypochlorous acid | inhibits at concentrations ca. 50 times less than the effective mono-N-chloramine concentrations; myeloperoxidase product, inhibition of the alpha-ketoglutarate dehydrogenase multienzyme complex in vitro | Sus scrofa | |
1.2.1.105 | mono-N-chloramine | myeloperoxidase product, inhibition of the alpha-ketoglutarate dehydrogenase multienzyme complex in vivo | Homo sapiens | |
1.2.1.105 | mono-N-chloramine | inhibits both lysate and in situ KGDHC activities in a concentration-dependent manner in three distinct phases | Mus musculus | |
1.2.1.105 | mono-N-chloramine | inhibits in a time- and concentration-dependent manner; myeloperoxidase product, inhibition of the alpha-ketoglutarate dehydrogenase multienzyme complex in vitro | Sus scrofa |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.105 | Ca2+ | - |
Homo sapiens | |
1.2.1.105 | Mg2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Homo sapiens | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Sus scrofa | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
1.2.1.105 | additional information | Homo sapiens | loss of enzyme activity contributes to the major loss of cerebral energy metabolism leading to a number of neurodegenerative disorders and Alzheimer's disease, myeloperoxidase activity is involved | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.105 | Homo sapiens | - |
- |
- |
1.2.1.105 | Mus musculus | - |
- |
- |
1.2.1.105 | Sus scrofa | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.2.1.105 | additional information | resulting in loss of enzyme complex activity | Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.105 | - |
Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.105 | brain | - |
Homo sapiens | - |
1.2.1.105 | heart | - |
Sus scrofa | - |
1.2.1.105 | microglia | - |
Homo sapiens | - |
1.2.1.105 | additional information | N2a cells | Mus musculus | - |
1.2.1.105 | Neuro-2a cell | neuroblastoma cells | Mus musculus | - |
1.2.1.105 | neuron | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Homo sapiens | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Sus scrofa | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
1.2.1.105 | additional information | loss of enzyme activity contributes to the major loss of cerebral energy metabolism leading to a number of neurodegenerative disorders and Alzheimer's disease, myeloperoxidase activity is involved | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.105 | alpha-ketoglutarate dehydrogenase complex | - |
Mus musculus |
1.2.1.105 | alpha-ketoglutarate dehydrogenase complex | - |
Homo sapiens |
1.2.1.105 | alpha-ketoglutarate dehydrogenase complex | - |
Sus scrofa |
1.2.1.105 | KGDHC | - |
Mus musculus |
1.2.1.105 | KGDHC | - |
Homo sapiens |
1.2.1.105 | KGDHC | - |
Sus scrofa |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.1.105 | 37 | - |
assay at | Sus scrofa |
1.2.1.105 | 37 | - |
in vivo assay at, N2a cells | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.105 | 7.4 | - |
assay at | Sus scrofa |
1.2.1.105 | 7.4 | - |
in vivo assay at, N2a cells | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.105 | NAD+ | - |
Homo sapiens | |
1.2.1.105 | NAD+ | - |
Sus scrofa | |
1.2.1.105 | thiamine diphosphate | - |
Sus scrofa | |
1.2.1.105 | thiamine diphosphate | thiamine deficiency results in decreased enzyme complex activity and selective neuronal loss | Homo sapiens |