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Literature summary extracted from

  • Coirini, H.; Gouezou, M.; Delespierre, B.; Liere, P.; Pianos, A.; Eychenne, B.; Schumacher, M.; Guennoun, R.
    Characterization and regulation of the 3beta-hydroxysteroid dehydrogenase isomerase enzyme in the rat sciatic nerve (2003), J. Neurochem., 84, 119-126.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 corticosterone 0.08 mM, 50% inhibition Rattus norvegicus
1.1.1.145 oestradiol 0.00024 mM, 50% inhibition Rattus norvegicus
1.1.1.145 progesterone 0.026 mM, 50% inhibition Rattus norvegicus
1.1.1.145 testosterone 0.0086 mM, 50% inhibition Rattus norvegicus
1.1.1.145 trilostane 0.004 mM, 50% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.145 0.001
-
 pregnenolone 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 pregnenolone + NAD+ Rattus norvegicus
-
 pregn-5-en-3,20-dione + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 sciatic nerve
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 pregnenolone + NAD+
-
 Rattus norvegicus pregn-5-en-3,20-dione + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.145 3beta-HSD
-
 Rattus norvegicus