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Literature summary extracted from
- Distribution and characteristics of D-amino acid and D-aspartate oxidases in fish tissues (2003), J. Exp. Zool. A, 295, 151-159.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.1 | meso-tartrate | - |
Oncorhynchus mykiss |  |
| 1.4.3.3 | benzoate | - |
Oncorhynchus mykiss | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.1 | 5.19 | - |
D-Aspartate | - |
Oncorhynchus mykiss | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.4.3.1 | peroxisome | - |
Pagrus major | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Scomber japonicus | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Cyprinus carpio | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Oncorhynchus mykiss | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Oncorhynchus keta | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Sardinops melanostictus | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Paralichthys olivaceus | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Lateolabrax japonicus | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Trachurus japonicus | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Oncorhynchus masou | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Plecoglossus altivelis | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Evynnis tumifrons | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Cololabis saira | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Thamnaconus tessellatus | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Verasper variegatus | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Pseudopleuronectes yokohamae | 5777 | - |
| 1.4.3.1 | peroxisome | - |
Chaunax fimbriatus | 5777 | - |
| 1.4.3.3 | peroxisome | - |
Oncorhynchus mykiss | 5777 | - |
| 1.4.3.3 | peroxisome | in kidney and hepatopancreas | Cyprinus carpio | 5777 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.1 | D-aspartate + H2O + O2 | Pagrus major | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Scomber japonicus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Cyprinus carpio | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Oncorhynchus mykiss | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Oncorhynchus keta | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Sardinops melanostictus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Paralichthys olivaceus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Lateolabrax japonicus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Trachurus japonicus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Oncorhynchus masou | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Plecoglossus altivelis | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Evynnis tumifrons | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Cololabis saira | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Thamnaconus tessellatus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Verasper variegatus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Pseudopleuronectes yokohamae | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | Chaunax fimbriatus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.3 | D-alanine + H2O + O2 | Cyprinus carpio | enzyme works as a metabolizing agent of exogenous and endogenous free D-Ala that is abundant in aquatic invertebrates such as crustaceans and bivalve mollusks, which are potential food sources of the fish. After oral administration of D-Ala at 0.005 mM/g body weight per day to carp for 30 days, enzyme activity increases by about 8fold, 3fold, and 1.5fold in intestine, hepatopancreas, and kidney, respectively, whereas no increase is found in brain | pyruvate + NH3 + H2O2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.1 | Chaunax fimbriatus | - |
anglerfish | - |
| 1.4.3.1 | Cololabis saira | - |
saury | - |
| 1.4.3.1 | Cyprinus carpio | - |
common carp | - |
| 1.4.3.1 | Evynnis tumifrons | - |
yellow sea bream | - |
| 1.4.3.1 | Lateolabrax japonicus | - |
japanese sea perch | - |
| 1.4.3.1 | Oncorhynchus keta | - |
chum salmon | - |
| 1.4.3.1 | Oncorhynchus masou | - |
land-locked masu salmon | - |
| 1.4.3.1 | Oncorhynchus mykiss | - |
rainbow trout | - |
| 1.4.3.1 | Pagrus major | - |
red sea bream | - |
| 1.4.3.1 | Paralichthys olivaceus | - |
olive flounder | - |
| 1.4.3.1 | Plecoglossus altivelis | - |
smelt fish | - |
| 1.4.3.1 | Pseudopleuronectes yokohamae | - |
marbled sole | - |
| 1.4.3.1 | Sardinops melanostictus | - |
sardine | - |
| 1.4.3.1 | Scomber japonicus | - |
chub mackerel | - |
| 1.4.3.1 | Thamnaconus tessellatus | - |
filefish | - |
| 1.4.3.1 | Trachurus japonicus | - |
horse mackerel | - |
| 1.4.3.1 | Verasper variegatus | - |
right-eyed flounder | - |
| 1.4.3.3 | Chaunax fimbriatus | - |
- |
- |
| 1.4.3.3 | Cololabis saira | - |
- |
- |
| 1.4.3.3 | Cyprinus carpio | - |
- |
- |
| 1.4.3.3 | Evynnis tumifrons | - |
- |
- |
| 1.4.3.3 | Lateolabrax japonicus | - |
- |
- |
| 1.4.3.3 | Oncorhynchus keta | - |
- |
- |
| 1.4.3.3 | Oncorhynchus masou | - |
- |
- |
| 1.4.3.3 | Oncorhynchus mykiss | - |
- |
- |
| 1.4.3.3 | Pagrus major | - |
- |
- |
| 1.4.3.3 | Paralichthys olivaceus | - |
- |
- |
| 1.4.3.3 | Plecoglossus altivelis | - |
- |
- |
| 1.4.3.3 | Pseudopleuronectes yokohamae | - |
- |
- |
| 1.4.3.3 | Sardinops melanostictus | - |
- |
- |
| 1.4.3.3 | Scomber japonicus | - |
- |
- |
| 1.4.3.3 | Thamnaconus tessellatus | - |
- |
- |
| 1.4.3.3 | Trachurus japonicus | - |
- |
- |
| 1.4.3.3 | Verasper variegatus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.4.3.1 | hepatopancreas | - |
Pagrus major | - |
| 1.4.3.1 | hepatopancreas | - |
Scomber japonicus | - |
| 1.4.3.1 | hepatopancreas | - |
Cyprinus carpio | - |
| 1.4.3.1 | hepatopancreas | - |
Oncorhynchus mykiss | - |
| 1.4.3.1 | hepatopancreas | - |
Oncorhynchus keta | - |
| 1.4.3.1 | hepatopancreas | - |
Sardinops melanostictus | - |
| 1.4.3.1 | hepatopancreas | - |
Lateolabrax japonicus | - |
| 1.4.3.1 | hepatopancreas | - |
Trachurus japonicus | - |
| 1.4.3.1 | hepatopancreas | - |
Oncorhynchus masou | - |
| 1.4.3.1 | hepatopancreas | - |
Plecoglossus altivelis | - |
| 1.4.3.1 | hepatopancreas | - |
Evynnis tumifrons | - |
| 1.4.3.1 | hepatopancreas | - |
Cololabis saira | - |
| 1.4.3.1 | hepatopancreas | - |
Thamnaconus tessellatus | - |
| 1.4.3.1 | hepatopancreas | - |
Verasper variegatus | - |
| 1.4.3.1 | hepatopancreas | - |
Pseudopleuronectes yokohamae | - |
| 1.4.3.1 | intestine | - |
Pagrus major | - |
| 1.4.3.1 | intestine | - |
Cyprinus carpio | - |
| 1.4.3.1 | intestine | - |
Oncorhynchus mykiss | - |
| 1.4.3.1 | intestine | - |
Sardinops melanostictus | - |
| 1.4.3.1 | intestine | - |
Lateolabrax japonicus | - |
| 1.4.3.1 | intestine | - |
Evynnis tumifrons | - |
| 1.4.3.1 | intestine | - |
Thamnaconus tessellatus | - |
| 1.4.3.1 | intestine | - |
Pseudopleuronectes yokohamae | - |
| 1.4.3.1 | intestine | - |
Chaunax fimbriatus | - |
| 1.4.3.1 | kidney | - |
Pagrus major | - |
| 1.4.3.1 | kidney | - |
Scomber japonicus | - |
| 1.4.3.1 | kidney | - |
Cyprinus carpio | - |
| 1.4.3.1 | kidney | - |
Oncorhynchus mykiss | - |
| 1.4.3.1 | kidney | - |
Sardinops melanostictus | - |
| 1.4.3.1 | kidney | - |
Paralichthys olivaceus | - |
| 1.4.3.1 | kidney | - |
Lateolabrax japonicus | - |
| 1.4.3.1 | kidney | - |
Trachurus japonicus | - |
| 1.4.3.1 | kidney | - |
Plecoglossus altivelis | - |
| 1.4.3.1 | kidney | - |
Evynnis tumifrons | - |
| 1.4.3.1 | kidney | - |
Cololabis saira | - |
| 1.4.3.1 | kidney | - |
Thamnaconus tessellatus | - |
| 1.4.3.1 | kidney | - |
Pseudopleuronectes yokohamae | - |
| 1.4.3.1 | kidney | - |
Chaunax fimbriatus | - |
| 1.4.3.3 | brain | - |
Cyprinus carpio | - |
| 1.4.3.3 | hepatopancreas | - |
Pagrus major | - |
| 1.4.3.3 | hepatopancreas | - |
Scomber japonicus | - |
| 1.4.3.3 | hepatopancreas | - |
Oncorhynchus keta | - |
| 1.4.3.3 | hepatopancreas | - |
Sardinops melanostictus | - |
| 1.4.3.3 | hepatopancreas | - |
Paralichthys olivaceus | - |
| 1.4.3.3 | hepatopancreas | - |
Lateolabrax japonicus | - |
| 1.4.3.3 | hepatopancreas | - |
Trachurus japonicus | - |
| 1.4.3.3 | hepatopancreas | - |
Oncorhynchus masou | - |
| 1.4.3.3 | hepatopancreas | - |
Plecoglossus altivelis | - |
| 1.4.3.3 | hepatopancreas | - |
Evynnis tumifrons | - |
| 1.4.3.3 | hepatopancreas | - |
Cololabis saira | - |
| 1.4.3.3 | hepatopancreas | - |
Thamnaconus tessellatus | - |
| 1.4.3.3 | hepatopancreas | - |
Verasper variegatus | - |
| 1.4.3.3 | hepatopancreas | - |
Pseudopleuronectes yokohamae | - |
| 1.4.3.3 | hepatopancreas | - |
Chaunax fimbriatus | - |
| 1.4.3.3 | intestine | - |
Pagrus major | - |
| 1.4.3.3 | intestine | - |
Sardinops melanostictus | - |
| 1.4.3.3 | intestine | - |
Paralichthys olivaceus | - |
| 1.4.3.3 | intestine | - |
Lateolabrax japonicus | - |
| 1.4.3.3 | intestine | - |
Oncorhynchus masou | - |
| 1.4.3.3 | intestine | - |
Evynnis tumifrons | - |
| 1.4.3.3 | intestine | - |
Thamnaconus tessellatus | - |
| 1.4.3.3 | intestine | - |
Verasper variegatus | - |
| 1.4.3.3 | intestine | - |
Pseudopleuronectes yokohamae | - |
| 1.4.3.3 | intestine | - |
Chaunax fimbriatus | - |
| 1.4.3.3 | intestine | low activity | Cyprinus carpio | - |
| 1.4.3.3 | kidney | - |
Pagrus major | - |
| 1.4.3.3 | kidney | - |
Scomber japonicus | - |
| 1.4.3.3 | kidney | - |
Oncorhynchus mykiss | - |
| 1.4.3.3 | kidney | - |
Oncorhynchus keta | - |
| 1.4.3.3 | kidney | - |
Sardinops melanostictus | - |
| 1.4.3.3 | kidney | - |
Paralichthys olivaceus | - |
| 1.4.3.3 | kidney | - |
Lateolabrax japonicus | - |
| 1.4.3.3 | kidney | - |
Trachurus japonicus | - |
| 1.4.3.3 | kidney | - |
Oncorhynchus masou | - |
| 1.4.3.3 | kidney | - |
Plecoglossus altivelis | - |
| 1.4.3.3 | kidney | - |
Evynnis tumifrons | - |
| 1.4.3.3 | kidney | - |
Cololabis saira | - |
| 1.4.3.3 | kidney | - |
Thamnaconus tessellatus | - |
| 1.4.3.3 | kidney | - |
Verasper variegatus | - |
| 1.4.3.3 | kidney | - |
Pseudopleuronectes yokohamae | - |
| 1.4.3.3 | kidney | high activity | Cyprinus carpio | - |
| 1.4.3.3 | liver | - |
Pagrus major | - |
| 1.4.3.3 | liver | - |
Scomber japonicus | - |
| 1.4.3.3 | liver | - |
Oncorhynchus keta | - |
| 1.4.3.3 | liver | - |
Sardinops melanostictus | - |
| 1.4.3.3 | liver | - |
Paralichthys olivaceus | - |
| 1.4.3.3 | liver | - |
Lateolabrax japonicus | - |
| 1.4.3.3 | liver | - |
Trachurus japonicus | - |
| 1.4.3.3 | liver | - |
Oncorhynchus masou | - |
| 1.4.3.3 | liver | - |
Plecoglossus altivelis | - |
| 1.4.3.3 | liver | - |
Evynnis tumifrons | - |
| 1.4.3.3 | liver | - |
Cololabis saira | - |
| 1.4.3.3 | liver | - |
Thamnaconus tessellatus | - |
| 1.4.3.3 | liver | - |
Verasper variegatus | - |
| 1.4.3.3 | liver | - |
Pseudopleuronectes yokohamae | - |
| 1.4.3.3 | liver | - |
Chaunax fimbriatus | - |
| 1.4.3.3 | liver | high activity | Cyprinus carpio | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.1 | cis-2,3-piperidinedicarboxylate + H2O + O2 | - |
Oncorhynchus mykiss | ? | - |
? | |
| 1.4.3.1 | D-aminoadipate + H2O + O2 | - |
Oncorhynchus mykiss | ? | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Pagrus major | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Scomber japonicus | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Cyprinus carpio | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Oncorhynchus mykiss | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Oncorhynchus keta | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Sardinops melanostictus | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Paralichthys olivaceus | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Lateolabrax japonicus | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Trachurus japonicus | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Oncorhynchus masou | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Plecoglossus altivelis | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Evynnis tumifrons | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Cololabis saira | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Thamnaconus tessellatus | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Verasper variegatus | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Pseudopleuronectes yokohamae | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-aspartate + H2O + O2 | - |
Chaunax fimbriatus | oxaloacetate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-glutamate + H2O + O2 | - |
Oncorhynchus mykiss | 2-oxoglutarate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-homocysteic acid + H2O + O2 | - |
Oncorhynchus mykiss | 2-oxo-4-sulfo-butanoate + NH3 + H2O2 | - |
? | |
| 1.4.3.1 | D-hydroxyglutarate + H2O + O2 | - |
Oncorhynchus mykiss | ? | - |
? | |
| 1.4.3.1 | meso-2,3-diaminosuccinate + H2O + O2 | - |
Oncorhynchus mykiss | ? | - |
? | |
| 1.4.3.1 | N-acetyl-DL-aspartate + H2O + O2 | - |
Oncorhynchus mykiss | oxaloacetate + acetylamine + H2O2 | - |
? | |
| 1.4.3.1 | N-methyl-D-aspartate + H2O + O2 | - |
Oncorhynchus mykiss | oxaloacetate + methylamine + H2O2 | - |
? | |
| 1.4.3.3 | D-alanine + H2O + O2 | - |
Cyprinus carpio | pyruvate + NH3 + H2O2 | - |
? | |
| 1.4.3.3 | D-alanine + H2O + O2 | - |
Oncorhynchus mykiss | pyruvate + NH3 + H2O2 | - |
? | |
| 1.4.3.3 | D-alanine + H2O + O2 | enzyme works as a metabolizing agent of exogenous and endogenous free D-Ala that is abundant in aquatic invertebrates such as crustaceans and bivalve mollusks, which are potential food sources of the fish. After oral administration of D-Ala at 0.005 mM/g body weight per day to carp for 30 days, enzyme activity increases by about 8fold, 3fold, and 1.5fold in intestine, hepatopancreas, and kidney, respectively, whereas no increase is found in brain | Cyprinus carpio | pyruvate + NH3 + H2O2 | - |
? | |
| 1.4.3.3 | D-phenylalanine + H2O + O2 | - |
Cyprinus carpio | phenylpyruvic acid + NH3 + H2O2 | - |
? | |
| 1.4.3.3 | D-phenylalanine + H2O + O2 | - |
Oncorhynchus mykiss | phenylpyruvic acid + NH3 + H2O2 | - |
? | |
| 1.4.3.3 | D-proline + H2O + O2 | best substrate | Cyprinus carpio | 2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
| 1.4.3.3 | D-proline + H2O + O2 | best substrate | Oncorhynchus mykiss | 2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.4.3.1 | D-AspO | - |
Oncorhynchus mykiss |
| 1.4.3.3 | D-AAO | - |
Pagrus major |
| 1.4.3.3 | D-AAO | - |
Scomber japonicus |
| 1.4.3.3 | D-AAO | - |
Cyprinus carpio |
| 1.4.3.3 | D-AAO | - |
Oncorhynchus mykiss |
| 1.4.3.3 | D-AAO | - |
Oncorhynchus keta |
| 1.4.3.3 | D-AAO | - |
Sardinops melanostictus |
| 1.4.3.3 | D-AAO | - |
Paralichthys olivaceus |
| 1.4.3.3 | D-AAO | - |
Lateolabrax japonicus |
| 1.4.3.3 | D-AAO | - |
Trachurus japonicus |
| 1.4.3.3 | D-AAO | - |
Oncorhynchus masou |
| 1.4.3.3 | D-AAO | - |
Plecoglossus altivelis |
| 1.4.3.3 | D-AAO | - |
Evynnis tumifrons |
| 1.4.3.3 | D-AAO | - |
Cololabis saira |
| 1.4.3.3 | D-AAO | - |
Thamnaconus tessellatus |
| 1.4.3.3 | D-AAO | - |
Verasper variegatus |
| 1.4.3.3 | D-AAO | - |
Pseudopleuronectes yokohamae |
| 1.4.3.3 | D-AAO | - |
Chaunax fimbriatus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.4.3.1 | 36 | - |
- |
Oncorhynchus mykiss |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.4.3.1 | 10 | - |
- |
Oncorhynchus mykiss |
| 1.4.3.3 | 7.4 | 8.2 | - |
Oncorhynchus mykiss |
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Release 2023.1 (January 2023)
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