Any feedback?
Literature summary extracted from
- Myometrial expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat pregnancy (2002), J. Endocrinol., 172, 519-526.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.B40 | progesterone | - |
Rattus norvegicus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.B40 | 0.000047 | - |
corticosterone | 37°C, in non-pregnant myometrium | Rattus norvegicus | |
| 1.1.1.B40 | 0.00006 | - |
corticosterone | 37°C, after day 23 of pregnancy | Rattus norvegicus | |
| 1.1.1.B40 | 0.000075 | - |
corticosterone | 37°C, after day 10 of pregnancy | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.B40 | 40000 | - |
x * 40000, immunoblot | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.B40 | corticosterone + NAD+ | Rattus norvegicus | - |
11-dehydrocorticosterone + NADH + H+ | - |
ir | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.B40 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.B40 | myometrium | - |
Rattus norvegicus | - |
| 1.1.1.B40 | uterus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.B40 | corticosterone + NAD+ | - |
Rattus norvegicus | 11-dehydrocorticosterone + NADH + H+ | - |
ir | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.B40 | ? | x * 40000, immunoblot | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 2 | - |
Rattus norvegicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.B40 | 0.0018 | - |
progesterone | probably minimal physiological importance | Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
