Literature summary extracted from

Ko, T.P.; Lin, J.J.; Hu, C.Y.; Hsu, Y.H.; Wang, A.H.; Liaw, S.H.
Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution (2003), J. Biol. Chem., 278, 19111-19117.

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
3.5.4.1	-	Saccharomyces cerevisiae

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.5.4.1	2-hydroxypyrimidine	binding structure modeling, inhibition mechanism, acts as a transition state analogue	Saccharomyces cerevisiae

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.5.4.1	Zn2+	1 metal ion is tightly bound to the active site, binding structure modeling, Fourier mapping	Saccharomyces cerevisiae

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.4.1	Saccharomyces cerevisiae	Q12178	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
3.5.4.1	cytosine + H2O = uracil + NH3	active site architecture and substrate binding, catalytic mechanism	Saccharomyces cerevisiae	a

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.4.1	5-fluorocytosine + H2O	-	Saccharomyces cerevisiae	5-fluorouracil + NH3	-	?
3.5.4.1	5-methylcytosine + H2O	-	Saccharomyces cerevisiae	thymine + NH3	-	?
3.5.4.1	cytosine + H2O	-	Saccharomyces cerevisiae	uracil + NH3	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.5.4.1	More	a monomer is a three-layered alpha/beta/alpha structure with a central beta sheet sandwiched on either side by alpha-helices	Saccharomyces cerevisiae

Synonyms

EC Number	Synonyms	Comment	Organism
3.5.4.1	CD	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)