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Literature summary extracted from

  • Sparla, F.; Pupillo, P.; Trost, P.
    The C-terminal extension of glyceraldehyde-3-phosphate dehydrogenase subunit B acts as an autoinhibitory domain regulated by thioredoxins and nicotinamide adenine dinucleotide (2002), J. Biol. Chem., 277, 44946-44952.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.13 C18S mutant of GapB subunit still shows stron redox regulation Spinacia oleracea
1.2.1.13 C274S mutant of GapB subunit still shows stron redox regulation Spinacia oleracea
1.2.1.13 C285S mutant of GapB subunit still shows stron redox regulation Spinacia oleracea
1.2.1.13 C349S mutant of GapB subunit is less redox-sensitive than GapB. Active tetramer, unable to aggregate to higher oligomers in presence of NAD+ Spinacia oleracea
1.2.1.13 C349S/C358S mutant of GapB subunit is less redox-sensitive than GapB. Active tetramer, unable to aggregate to higher oligomers in presence of NAD+ Spinacia oleracea
1.2.1.13 c358S mutant of GapB subunit is less redox-sensitive than GapB. Active tetramer, unable to aggregate to higher oligomers in presence of NAD+ Spinacia oleracea

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.13 NAD+ a regulatory disulfide between Cys359 and Cys358 of the C-terminal extension of GapB does form in presence of oxidized thioredoxin. This covalent modification is required for the NAD+-dependent association into higher oligomers and inhibition of the NADPH-dependent activity Spinacia oleracea
1.2.1.13 thioredoxin a regulatory disulfide between Cys359 and Cys358 of the C-terminal extension of GapB does form in presence of oxidized thioredoxin. This covalent modification is required for the NAD+-dependent association into higher oligomers and inhibition of the NADPH-dependent activity Spinacia oleracea

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.13 chloroplast
-
 Spinacia oleracea 9507
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.13 Spinacia oleracea
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.2.1.13 GAPDH
-
 Spinacia oleracea