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Literature summary extracted from

  • Lee, Y.; Ling, K.Q.; Lu, X.; Silverman, R.B.; Shepard, E.M.; Dooley, D.M.; Sayre, L.M.
    3-Pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases (2002), J. Am. Chem. Soc., 124, 12135-12143.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.21 3-(2-naphthyl)-3-pyrroline 0.2 mM, inactivation of BPAO by 3-aryl-3-pyrrolines Bos taurus
1.4.3.21 3-(4-methoxy-3-nitrophenyl)-3-pyrroline 0.015 mM, inactivation of BPAO by 3-aryl-3-pyrrolines Bos taurus
1.4.3.21 3-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole hydrochloride 0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines Bos taurus
1.4.3.21 3-biphenyl-4-yl-2,5-dihydro-1H-pyrrole hydrochloride 0.1 mM, inactivation of BPAO by 3-aryl-3-pyrrolines Bos taurus
1.4.3.21 3-naphthalen-1-yl-2,5-dihydro-1H-pyrrole hydrochloride 0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines Bos taurus
1.4.3.21 3-phenyl-3-pyrroline 0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines Bos taurus
1.4.3.21 3-pyrroline
-
 Bos taurus
1.4.3.21 4-(2,5-dihydro-1H-pyrrol-3-yl)-N,N-dimethylaniline hydrochloride 0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines Bos taurus
1.4.3.21 additional information 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 0.252
-
 3-phenyl-3-pyrroline pH 7.2, 30°C Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.21 copper copper-containing amine oxidase Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Bos taurus
-
-
-
1.4.3.4 Bos taurus P56560
-
-
1.4.3.21 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Bos taurus
-
1.4.3.21 liver
-
 Bos taurus
-
1.4.3.21 plasma
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 3-phenyl-3-pyrroline + H2O + O2
-
 Bos taurus 4-phenyl-2H-pyrrole + ? 4-phenyl-2H-pyrrole rapidly tautomerizes to 5-phenyl-2H-pyrrole ?
1.4.3.4 3-pyrroline + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases Bos taurus ? + H2O2 + NH3
-
 ?
1.4.3.4 pyrrolidine + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2
-
 Bos taurus ? + H2O2 + NH3
-
 ?
1.4.3.21 pyrrolidine + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2
-
 Bos taurus ? + H2O2 + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-B
-
 Bos taurus
1.4.3.4 monoamine oxidase B
-
 Bos taurus
1.4.3.21 bovine plasma amine oxidase
-
 Bos taurus
1.4.3.21 BPAO
-
 Bos taurus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.4 834
-
 3-phenyl-3-pyrroline pH 7.2, 30°C Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 flavin
-
 Bos taurus
1.4.3.21 2,4,5-trihydroxyphenylalanine quinone
-
 Bos taurus