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Literature summary extracted from

  • Sylvestre, M.
    Genetically modified organisms to remediate polychlorinated biphenyls. Where do we stand? (2004), Int. Biodeter. Biodegrad., 54, 153-162.
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.56
-
 Burkholderia sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.56 cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ Comamonas testosteroni
-
 biphenyl-2,3-diol + NADH
-
 ?
1.3.1.56 cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ Burkholderia sp.
-
 biphenyl-2,3-diol + NADH
-
 ?
1.3.1.56 cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ Burkholderia sp. LB400
-
 biphenyl-2,3-diol + NADH
-
 ?
1.3.1.56 additional information Comamonas testosteroni enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview ?
-
 ?
1.3.1.56 additional information Burkholderia sp. enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview ?
-
 ?
1.3.1.56 additional information Burkholderia sp. LB400 enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.56 Burkholderia sp.
-
 enzyme BphB
-
1.3.1.56 Burkholderia sp. LB400
-
 enzyme BphB
-
1.3.1.56 Comamonas testosteroni
-
 gene bphB
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.56
-
 Comamonas testosteroni
1.3.1.56
-
 Burkholderia sp.

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.1.56 cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+ catalytic triad is formed by the conserved residues SEr142, Tyr153, and Lys159 Comamonas testosteroni
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.56 2,2',5,5'-tetrachlorobiphenyl + NAD+
-
 Comamonas testosteroni 2,2',5,5'-tetrachloro-3,4-dihydroxybiphenyl + NADH
-
 ?
1.3.1.56 2,2',5,5'-tetrachlorobiphenyl + NAD+
-
 Burkholderia sp. 2,2',5,5'-tetrachloro-3,4-dihydroxybiphenyl + NADH
-
 ?
1.3.1.56 2,2',5,5'-tetrachlorobiphenyl + NAD+
-
 Burkholderia sp. LB400 2,2',5,5'-tetrachloro-3,4-dihydroxybiphenyl + NADH
-
 ?
1.3.1.56 cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
-
 Comamonas testosteroni biphenyl-2,3-diol + NADH
-
 ?
1.3.1.56 cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
-
 Burkholderia sp. biphenyl-2,3-diol + NADH
-
 ?
1.3.1.56 cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
-
 Burkholderia sp. LB400 biphenyl-2,3-diol + NADH
-
 ?
1.3.1.56 additional information enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview Comamonas testosteroni ?
-
 ?
1.3.1.56 additional information enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview Burkholderia sp. ?
-
 ?
1.3.1.56 additional information enzyme shows a broad substrate specificity Comamonas testosteroni ?
-
 ?
1.3.1.56 additional information enzyme shows a broad substrate specificity Burkholderia sp. ?
-
 ?
1.3.1.56 additional information enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview Burkholderia sp. LB400 ?
-
 ?
1.3.1.56 additional information enzyme shows a broad substrate specificity Burkholderia sp. LB400 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.56 2,3-dihydro-2,3-dehydroxybiphenyl-2,3-dehydrogenase
-
 Comamonas testosteroni
1.3.1.56 2,3-dihydro-2,3-dehydroxybiphenyl-2,3-dehydrogenase
-
 Burkholderia sp.
1.3.1.56 BphB
-
 Comamonas testosteroni
1.3.1.56 BphB
-
 Burkholderia sp.
1.3.1.56 More enzyme belongs to the short-chain alcohol dehydrogenase/reductase family Comamonas testosteroni
1.3.1.56 More enzyme belongs to the short-chain alcohol dehydrogenase/reductase family Burkholderia sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.56 additional information NADP+ is a poor cofactor, probably due to Asp at position 36 Comamonas testosteroni
1.3.1.56 NAD+
-
 Burkholderia sp.
1.3.1.56 NAD+ 260fold preferred over NADP+ Comamonas testosteroni