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Literature summary extracted from
- Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues (2002), FEBS Lett., 531, 489-493.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.1.1.71 | expression in insect SF9 cells | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.71 | 0.08 | - |
all-trans-retinal | pH 7.4, 37°C | Homo sapiens |  |
| 1.1.1.71 | 0.32 | - |
NADPH | pH 7.4, 37°C | Homo sapiens | |
| 1.1.1.71 | 0.4 | - |
all-trans-retinol | pH 7.4, 37°C | Homo sapiens | |
| 1.1.1.71 | 0.65 | - |
NADP+ | pH 7.4, 37°C | Homo sapiens | |
| 1.1.1.71 | 1060 | - |
NAD+ | pH 7.4, 37°C | Homo sapiens | |
| 1.1.1.71 | 1200 | - |
NADH | pH 7.4, 37°C | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.71 | membrane | - |
Homo sapiens | 16020 | - |
| 1.1.1.71 | microsome | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.71 | 37000 | - |
SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.71 | Homo sapiens | Q9HBH5 | - |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.1.1.71 | a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+ | the human pancreas protein 2 has a retinal reductase activity | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.71 | adrenal gland | - |
Homo sapiens | - |
| 1.1.1.71 | brain | - |
Homo sapiens | - |
| 1.1.1.71 | heart | - |
Homo sapiens | - |
| 1.1.1.71 | kidney | - |
Homo sapiens | - |
| 1.1.1.71 | liver | - |
Homo sapiens | - |
| 1.1.1.71 | mammary gland | - |
Homo sapiens | - |
| 1.1.1.71 | pancreas | - |
Homo sapiens | - |
| 1.1.1.71 | placenta | - |
Homo sapiens | - |
| 1.1.1.71 | prostate gland | - |
Homo sapiens | - |
| 1.1.1.71 | skeletal muscle | - |
Homo sapiens | - |
| 1.1.1.71 | spinal cord | - |
Homo sapiens | - |
| 1.1.1.71 | stomach | - |
Homo sapiens | - |
| 1.1.1.71 | thyroid gland | - |
Homo sapiens | - |
| 1.1.1.71 | trachea | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.71 | all-trans-retinol + NADP+ | - |
Homo sapiens | all-trans-retinal + NADPH + H+ | - |
r | |
| 1.1.1.71 | retinaldehyde + NADH | - |
Homo sapiens | retinol + NAD+ | - |
? | |
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Release 2023.1 (January 2023)
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