EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.3.99.5 | additional information | expression of isozyme 5alpha-R2 is induced by testosterone and dihydrotestosterone | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.99.5 | quantitative expression analysis of isozymes 5alpha-R1 and 5alpha-R2 in brain | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.99.5 | additional information | expression of isozyme 5alpha-R1 is inhibited by testosterone and dihydrotestosterone | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.99.5 | deoxycorticosterone + reduced acceptor | Rattus norvegicus | - |
21-hydroxy-5alpha-pregnan-3,20-dione + acceptor | - |
? | |
1.3.99.5 | additional information | Rattus norvegicus | the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview | ? | - |
? | |
1.3.99.5 | progesterone + reduced acceptor | Rattus norvegicus | - |
pregnane-3,20-dione + acceptor | - |
? | |
1.3.99.5 | testosterone + reduced acceptor | Rattus norvegicus | - |
5alpha-dihydrotestosterone + acceptor | 5alpha-dihydrotestosterone is a more potent androgen | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.99.5 | Rattus norvegicus | - |
male Wistar rats, 2 isozymes 5alpha-R1 and 5alpha-R2 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.99.5 | brain | adult, isozymes 5alpha-R1 and 5alpha-R2 | Rattus norvegicus | - |
1.3.99.5 | cerebral cortex | prefrontal, expression of isozymes 5alpha-R1 and 5alpha-R2 | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.99.5 | deoxycorticosterone + reduced acceptor | - |
Rattus norvegicus | 21-hydroxy-5alpha-pregnan-3,20-dione + acceptor | - |
? | |
1.3.99.5 | additional information | the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview | Rattus norvegicus | ? | - |
? | |
1.3.99.5 | progesterone + reduced acceptor | - |
Rattus norvegicus | pregnane-3,20-dione + acceptor | - |
? | |
1.3.99.5 | testosterone + reduced acceptor | - |
Rattus norvegicus | 5alpha-dihydrotestosterone + acceptor | - |
? | |
1.3.99.5 | testosterone + reduced acceptor | - |
Rattus norvegicus | 5alpha-dihydrotestosterone + acceptor | 5alpha-dihydrotestosterone is a more potent androgen | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.99.5 | 5alpha-R | - |
Rattus norvegicus |
1.3.99.5 | steroid 5alpha-reductase | - |
Rattus norvegicus |