EC Number | Cloned (Comment) | Organism |
---|---|---|
1.4.3.5 | expression in Escherichia coli | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.4.3.5 | DELTA1-56 | 3.35fold increase in KM-value for pyridoxamine 5'-phosphate compared to wild-type enzyme, 2.95fold increase in KM-value for pyridoxine 5'-phosphate compared to wild-type enzyme, 6fold increase in KI-value for pyridoxal 5'-phosphate compared to wild-type enzyme | Homo sapiens |
1.4.3.5 | DELTA238-262 | inactive mutant enzyme | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.4.3.5 | pyridoxal 5'-phosphate | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.3.5 | 0.0021 | - |
pyridoxamine 5'-phosphate | pH 8.0, 25°C, wild-type enzyme | Homo sapiens | |
1.4.3.5 | 0.0062 | - |
pyridoxine 5'-phosphate | pH 8.0, 25°C, wild-type enzyme | Homo sapiens | |
1.4.3.5 | 0.0062 | - |
pyridoxamine 5'-phosphate | pH 8.0, 25°C, mutant enzyme DELTA1-56 | Homo sapiens | |
1.4.3.5 | 0.0208 | - |
pyridoxine 5'-phosphate | pH 8.0, 25°C, mutant enzyme DELTA1-56 | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.4.3.5 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.4.3.5 | A-549 cell | 0.7% of the activity in liver | Homo sapiens | - |
1.4.3.5 | adrenal gland | 11.5% of the activity in liver | Homo sapiens | - |
1.4.3.5 | amygdala | 13.0% of the activity in liver | Homo sapiens | - |
1.4.3.5 | aorta | 1.2% of the activity in liver | Homo sapiens | - |
1.4.3.5 | atrium | 14% of the activity in liver detected in left atrium, 11.6% of the activity in liver detected in tight atrium | Homo sapiens | - |
1.4.3.5 | bladder | 6.8% of the activity in liver | Homo sapiens | - |
1.4.3.5 | bone marrow | 11.2% of the activity in liver | Homo sapiens | - |
1.4.3.5 | brain | 23.8% of the activity in liver | Homo sapiens | - |
1.4.3.5 | caudate nucleus | 19.0% of the activity in liver | Homo sapiens | - |
1.4.3.5 | caudate putamen | 2.0% of the activity in liver | Homo sapiens | - |
1.4.3.5 | cerebellum | 13.3% of the activity in liver detected in left cerebellum, 25.0% of the activity in liver detected in the right cerebellum | Homo sapiens | - |
1.4.3.5 | cerebral cortex | 25.9% of the activity in liver | Homo sapiens | - |
1.4.3.5 | cerebral gyrus | of cerebral cortex, 9.5% of the activity in liver | Homo sapiens | - |
1.4.3.5 | colon | 1.2% of the activity in liver detected in ascending colon, 7.9% of the activity in liver is detected in transverse colon, 2.8% of the activity in liver is detected in descending colon | Homo sapiens | - |
1.4.3.5 | corpus callosum | 18.4% of the activity in liver | Homo sapiens | - |
1.4.3.5 | DAUDI cell | 1.1% of the activity in liver | Homo sapiens | - |
1.4.3.5 | duodenum | 9.3% of the activity in liver | Homo sapiens | - |
1.4.3.5 | esophagus | 7.5% of the activity in liver | Homo sapiens | - |
1.4.3.5 | frontal lobe | 12.4% of the activity in liver | Homo sapiens | - |
1.4.3.5 | heart | 3.7% of the activity in liver | Homo sapiens | - |
1.4.3.5 | HeLa-S3 cell | 3.5% of the activity in liver | Homo sapiens | - |
1.4.3.5 | hippocampus | 12.3% of the activity in liver | Homo sapiens | - |
1.4.3.5 | HL-60 cell | 2.3% of the activity in liver | Homo sapiens | - |
1.4.3.5 | ileocecum | 6.1% of the activity in liver | Homo sapiens | - |
1.4.3.5 | ileum | 5.8% of the activity in liver | Homo sapiens | - |
1.4.3.5 | interventricular septum | 16.2% of the activity in liver | Homo sapiens | - |
1.4.3.5 | jejunum | 13.3% of the activity in liver | Homo sapiens | - |
1.4.3.5 | K-562 cell | 2.5% of the activity in liver | Homo sapiens | - |
1.4.3.5 | kidney | 85.6% of the activity in liver | Homo sapiens | - |
1.4.3.5 | left ventricle | 4.1% of the activity in liver detected in the left ventricle | Homo sapiens | - |
1.4.3.5 | leukocyte | from peripheral blood, 0.4% of the activity in liver | Homo sapiens | - |
1.4.3.5 | liver | 30.2% of the activity of adult liver is detected in foetal liver | Homo sapiens | - |
1.4.3.5 | lung | 4.6% of the activity in liver | Homo sapiens | - |
1.4.3.5 | lymph node | 4.6% of the activity in liver | Homo sapiens | - |
1.4.3.5 | medulla oblongata | 5.0% of the activity in liver | Homo sapiens | - |
1.4.3.5 | MOLT-4 cell | 8.1% of the activity in liver | Homo sapiens | - |
1.4.3.5 | nucleus accumbens | 5.2% of the activity in liver | Homo sapiens | - |
1.4.3.5 | occipital lobe | 14.7% of the activity in liver | Homo sapiens | - |
1.4.3.5 | ovary | 4.3% of the activity in liver | Homo sapiens | - |
1.4.3.5 | pancreas | 2.5% of the activity in liver | Homo sapiens | - |
1.4.3.5 | parietal lobe | 13.6% of the activity in liver | Homo sapiens | - |
1.4.3.5 | placenta | 30.2% of the activity in liver | Homo sapiens | - |
1.4.3.5 | pons | 6.2% of the activity in liver | Homo sapiens | - |
1.4.3.5 | prostate gland | 16.5% of the activity in liver | Homo sapiens | - |
1.4.3.5 | RAJI cell | 6.5% of the activity in liver | Homo sapiens | - |
1.4.3.5 | rectum | 2.3% of the activity in liver | Homo sapiens | - |
1.4.3.5 | right ventricle | 20.5% of the activity in liver detected in the right ventricle | Homo sapiens | - |
1.4.3.5 | salivary gland | 10% of the activity in liver | Homo sapiens | - |
1.4.3.5 | skeletal muscle | 34.1% of the activity in liver | Homo sapiens | - |
1.4.3.5 | spinal cord | 1.6% of the activity in liver | Homo sapiens | - |
1.4.3.5 | spleen | 13.5% of the activity in liver | Homo sapiens | - |
1.4.3.5 | stomach | 17.2% of the activity in liver | Homo sapiens | - |
1.4.3.5 | SW-480 cell | 5.1% of the activity in liver | Homo sapiens | - |
1.4.3.5 | temporal lobe | 12.6% of the activity in liver | Homo sapiens | - |
1.4.3.5 | testis | 8.4% of the activity in liver | Homo sapiens | - |
1.4.3.5 | thalamus | 10.8% of the activity in liver | Homo sapiens | - |
1.4.3.5 | thymus | 6.4% of the activity in liver | Homo sapiens | - |
1.4.3.5 | thyroid gland | 20.3% of the activity in liver | Homo sapiens | - |
1.4.3.5 | trachea | 4.8% of the activity in liver | Homo sapiens | - |
1.4.3.5 | uterus | 2.9% of the activity in liver | Homo sapiens | - |
1.4.3.5 | vermiform appendix | 0.7% of the activity in liver | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.4.3.5 | pyridoxamine 5'-phosphate + H2O + O2 | - |
Homo sapiens | pyridoxal 5'-phosphate + NH3 + H2O2 | - |
? | |
1.4.3.5 | pyridoxine 5'-phosphate + H2O + O2 | - |
Homo sapiens | pyridoxal 5'-phosphate + H2O2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.4.3.5 | PNPO | - |
Homo sapiens |
1.4.3.5 | pyridoxine 5'-phosphate oxidase | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.3.5 | 3.8 | - |
pyridoxal 5'-phosphate | pH 8.5, 25°C, pyridoxine 5'-phosphate as substrate, wild-type enzyme | Homo sapiens | |
1.4.3.5 | 23 | - |
pyridoxal 5'-phosphate | pH 8.5, 25°C, pyridoxine 5'-phosphate as substrate, mutant enzyme DELTA1-56 | Homo sapiens |