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Literature summary extracted from

  • Tursky, T.; Bandzuchova, E.
    An endogenous activator of renal glutamic acid decarboxylase effects of adenosine triphosphate, phosphate and chloride on the activity of this enzyme (1999), Eur. J. Biochem., 262, 696-703.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.15 ADP 2 mM, activation to about 170% of control without detergent. Activation to about 210% of control in presence of 1% Triton X-100 Rattus norvegicus
4.1.1.15 AMP 2 mM, activation to about 125% of control without detergent. Activation to about 140% of control in presence of 1% Triton X-100 Rattus norvegicus
4.1.1.15 ATP 2 mM, activation to about 150% of control in presence of 1% Triton, inhibition to 20% of control without detergent Rattus norvegicus
4.1.1.15 CTP 2 mM, activation to about 110% of control without detergent. Activation to about 200% of control in presence of 1% Triton X-100 Rattus norvegicus
4.1.1.15 GTP 2 mM, activation to about 125% of control without detergent. Activation to about 190% of control in presence of 1% Triton X-100 Rattus norvegicus
4.1.1.15 UTP 2 mM, activation to about 140% of control without detergent. Activation to about 190% of control in presence of 1% Triton X-100 Rattus norvegicus

General Stability

EC Number General Stability Organism
4.1.1.15 ATP and phosphate together with chlorides stabilize renal GAD Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.15 ATP in presence of leupeptin in freshly prepared homogenates. Inhibition of enzyme from homogenates stored without Triton X-100 for 24 h at 4°C Rattus norvegicus
4.1.1.15 EGTA 0.5 mM, 20% inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.15 membrane the renal enzyme differs from the brain and pancreatic enzyme by its strong binding to membranes that is not influenced by detergents Rattus norvegicus 16020
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Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.15 KBr 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus
4.1.1.15 KCl 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus
4.1.1.15 LiCl 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus
4.1.1.15 NaBr 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus
4.1.1.15 NaCl 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.15 Rattus norvegicus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.15 kidney the renal enzyme differs from the brain and pancreatic enzyme by its strong binding to membranes that is not influenced by detergents Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.15 L-Glu
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 Rattus norvegicus 4-Aminobutanoate + CO2
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 ?