Literature summary extracted from

Velasco-Garcia, R.; Chacon-Aguilar, V.M.; Hervert-Hernandez, D.; Munoz-Clares, R.A.
Inactivation of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves by disulfiram (2003), Chem. Biol. Interact., 143-144, 149-158.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.2.1.8	Disulfiram	inactivates in a time- and dose-dependent manner, inactivation kinetics is biphasic with second-order inactivation rate constants at pH 7.5 of 6.8 per M per sec and 0.33 per M per sec, inactivation is faster in presence of NAD(P)+ than in absence, inactivation is increased by NAD(P)H and betaine aldehyde, reactivation by dithiothreitol, inactivation is reversible by glutathione	Amaranthus hypochondriacus
1.2.1.8	Disulfiram	inactivates in a time- and dose-dependent manner, inactivation kinetics is monophasic with a second-order inactivation rate constant at pH 6.0 of 4.9 per M per sec and at pH 8.8 of 1000 per M per sec, inactivation is faster in presence of NAD(P)+ than in absence, inactivation is protected by NAD(P)H and betaine aldehyde, reactivation by dithiothreitol, inactivation is reversible by glutathione	Pseudomonas aeruginosa

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.2.1.8	Amaranthus hypochondriacus	-	-	-
1.2.1.8	Pseudomonas aeruginosa	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.2.1.8	leaf	-	Pseudomonas aeruginosa	-
1.2.1.8	leaf	-	Amaranthus hypochondriacus	-

Synonyms

EC Number	Synonyms	Comment	Organism
1.2.1.8	BADH	-	Pseudomonas aeruginosa
1.2.1.8	BADH	-	Amaranthus hypochondriacus

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Release 2023.1 (January 2023)