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Literature summary extracted from

  • Valenzuela-Soto, E.M.; Velasco-Garcia, R.; Mujica-Jimenez, C.; Gaviria-Gonzalez, L.L.; Munoz-Clares, R.A.
    Monovalent cations requirements for the stability of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, porcine kidney and amaranth leaves (2003), Chem. Biol. Interact., 143-144, 139-148.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.2.1.8 the enzyme is stable in absence of K+ even at very low enzyme concentrations Amaranthus hypochondriacus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.8 K+ required for maintenance of its active conformation. At low concentrations, the enzyme is totally inactivated upon removal of K+. NAD+ protects against inactivation by absence of K+, betaine aldehyde affords partial protection. NH4+ but not Na+ can mimic the effect of K+. At pH 7.0 in the absence of K+ in a buffer of low ionic strength, the active tetrameric form dissociates into inactive monomers Pseudomonas aeruginosa
1.2.1.8 K+ required for maintenance of its active conformation. At low concentrations, the enzyme is totally inactivated upon removal of K+. NAD+ protects against inactivation by absence of K+, betaine aldehyde incrrases the inactivation rate of the enzyme. NH4+ but not Na+ can mimic the effect of K+. At pH 7.0 in the absence of K+ in a buffer of low ionic strength, the active tetrameric form dissociates into inactive monomers Sus scrofa
1.2.1.8 Na+ can mimic the effect of K+ Sus scrofa
1.2.1.8 NH4+ can mimic the effect of K+ Sus scrofa
1.2.1.8 NH4+ can mimic the effect of K+ Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.8 Amaranthus hypochondriacus
-
-
-
1.2.1.8 Pseudomonas aeruginosa
-
-
-
1.2.1.8 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.8 kidney
-
 Sus scrofa
-
1.2.1.8 leaf
-
 Amaranthus hypochondriacus
-

Subunits

EC Number Subunits Comment Organism
1.2.1.8 tetramer at pH 7.0 in the absence of K+ in a buffer of low ionic strength, the active tetrameric form dissociates into inactive dimers Sus scrofa
1.2.1.8 tetramer at pH 7.0 in the absence of K+ in a buffer of low ionic strength, the active tetrameric form dissociates into inactive monomers Pseudomonas aeruginosa

Synonyms

EC Number Synonyms Comment Organism
1.2.1.8 BADH
-
 Sus scrofa
1.2.1.8 BADH
-
 Pseudomonas aeruginosa
1.2.1.8 BADH
-
 Amaranthus hypochondriacus