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Literature summary extracted from

  • Kondo, K.; Uritani, I.; Oba, K.
    Induction mechanism of 3-hydroxy-3-methylglutaryl-CoA reductase in potato tuber and sweet potato root tissues (2003), Biosci. Biotechnol. Biochem., 67, 1007-1017.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.34 additional information 4fold enzyme induction by root cutting within 2 h, and strong induction by infection with Phytophtora infestans, maximal 66fold after 2 h, induction mechanism Ipomoea batatas
1.1.1.34 additional information about 40fold enzyme induction by root cutting within 14 h, and about 875fold induction by infection with Phytophtora infestans after 22 h, induction mechanism Solanum tuberosum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 additional information the hybrid is resistant to race 0 of Phytophtora infestans Solanum x edinense

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 microsome
-
 Solanum tuberosum
-
-
1.1.1.34 microsome
-
 Ipomoea batatas
-
-
1.1.1.34 microsome
-
 Solanum x edinense
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.34 Hg2+ induces the enzyme in cut roots treated with HgCl2 Ipomoea batatas

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Solanum tuberosum
-
 (R)-mevalonate + CoA + 2 NADP+
-
 r
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Ipomoea batatas
-
 (R)-mevalonate + CoA + 2 NADP+
-
 r
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Solanum x edinense
-
 (R)-mevalonate + CoA + 2 NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Ipomoea batatas
-
 cv. Norin 1
-
1.1.1.34 Solanum tuberosum
-
 cv. Irish Cobbler
-
1.1.1.34 Solanum x edinense
-
 cv. Rishiri, interspecific hybrid
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.34 phosphoprotein regulation of the plant enzyme by phosphorylation/dephosphorylation Solanum tuberosum
1.1.1.34 phosphoprotein regulation of the plant enzyme by phosphorylation/dephosphorylation Ipomoea batatas
1.1.1.34 phosphoprotein regulation of the plant enzyme by phosphorylation/dephosphorylation Solanum x edinense

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.34 4380fold to homogeneity from microsomes by solubilization with trypsin, and affinity chromatography on 2',5'-ADP-resin and HMG-CoA-hexane resin Solanum tuberosum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 root
-
 Ipomoea batatas
-
1.1.1.34 tuber
-
 Solanum tuberosum
-
1.1.1.34 tuber
-
 Solanum x edinense
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.34 additional information
-
-
 Ipomoea batatas
1.1.1.34 7800
-
 purified enzyme Solanum tuberosum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Solanum tuberosum (R)-mevalonate + CoA + 2 NADP+
-
 r
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Ipomoea batatas (R)-mevalonate + CoA + 2 NADP+
-
 r
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Solanum x edinense (R)-mevalonate + CoA + 2 NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA reductase
-
 Solanum tuberosum
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA reductase
-
 Ipomoea batatas
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA reductase
-
 Solanum x edinense
1.1.1.34 HMGR
-
 Solanum tuberosum
1.1.1.34 HMGR
-
 Ipomoea batatas
1.1.1.34 HMGR
-
 Solanum x edinense

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.34 30
-
 assay at Solanum tuberosum
1.1.1.34 30
-
 assay at Ipomoea batatas
1.1.1.34 30
-
 assay at Solanum x edinense

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.34 7.5
-
 assay at Solanum tuberosum
1.1.1.34 7.5
-
 assay at Ipomoea batatas
1.1.1.34 7.5
-
 assay at Solanum x edinense

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Solanum tuberosum