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Literature summary extracted from

  • Garrastazu, C.; Gimenez, M.J.; Iniesta, M.P.; Aranguez, M.I.; Ruiz-Amil, M.
    Propionyl-CoA synthetase in mammary gland and liver of cows (1991), Rev. Esp. Fisiol., 47, 63-68.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.17 ATP substrate inhibition at high concentrations, above 20 mM for the liver enzyme and above 10 mM for the mammary gland enzyme Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.17 0.9
-
 CoA cow liver enzyme Bos taurus
6.2.1.17 1
-
 CoA mammary gland enzyme, cow Bos taurus
6.2.1.17 1.1
-
 ATP mammary gland enzyme, cow Bos taurus
6.2.1.17 1.3
-
 propanoate mamary gland enzyme, cow, Bos taurus
6.2.1.17 4.8
-
 ATP cow liver enzyme Bos taurus
6.2.1.17 5.3
-
 propanoate cow liver enzyme Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.17 Mg2+ required Bos taurus
6.2.1.17 Mg2+ Km: 5.5 mM for cow liver enzyme, Km: 1.6 mM for mammary gland enzyme Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.17 Bos taurus
-
 calf and midlactation cow
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.17 liver
-
 Bos taurus
-
6.2.1.17 mammary gland of midlactation cow, no activity in calf Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.17 ATP + acetate + CoA 22% of the activity relative to propanonate Bos taurus AMP + diphosphate + acetyl-CoA
-
 ?
6.2.1.17 ATP + butyrate + CoA 27% of the activity relative to propanoate Bos taurus AMP + diphosphate + butyryl-CoA
-
 ?
6.2.1.17 ATP + propanoate + CoA
-
 Bos taurus AMP + diphosphate + propanoyl-CoA
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.2.1.17 40
-
 cow liver enzyme Bos taurus
6.2.1.17 50
-
 mammary gland enzyme, cow Bos taurus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6.2.1.17
-
 30 5 min, maximal stability, cow liver and mammary gland enzymes Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.17 7.5 8.5 cow liver enzyme Bos taurus
6.2.1.17 8 9 mammary gland enzyme, cow Bos taurus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
6.2.1.17 8 9 cow liver enzyme Bos taurus
6.2.1.17 8.5 9 mammary gland enzyme, cow Bos taurus