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Literature summary extracted from

  • Pasti, C.; Rinaldi, E.; Cervellati, C.; Dallocchio, F.; Hardre, R.; Salmon, L.; Hanau, S.
    Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei (2003), Bioorg. Med. Chem., 11, 1207-1214.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.44 overexpression in Escherichia coli Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 1,5-diphospho-D-ribulose
-
 Ovis aries
1.1.1.44 1,5-diphospho-D-ribulose
-
 Trypanosoma brucei
1.1.1.44 1,5-diphospho-ribitol
-
 Ovis aries
1.1.1.44 1,5-diphospho-ribitol
-
 Trypanosoma brucei
1.1.1.44 2-deoxy-6-phosphono-D-gluconate
-
 Ovis aries
1.1.1.44 2-deoxy-6-phosphono-D-gluconate
-
 Trypanosoma brucei
1.1.1.44 4-phospho-D-erythronate bio-isosteric analogue Ovis aries
1.1.1.44 4-phospho-D-erythronate bio-isosteric analogue Trypanosoma brucei
1.1.1.44 4-phospho-D-erythrose bio-isosteric analogue Ovis aries
1.1.1.44 4-phospho-D-erythrose bio-isosteric analogue Trypanosoma brucei
1.1.1.44 5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
 Ovis aries
1.1.1.44 5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
 Trypanosoma brucei
1.1.1.44 5-deoxy-5-phosphonoD-arabinonate
-
 Ovis aries
1.1.1.44 5-deoxy-5-phosphonoD-arabinonate
-
 Trypanosoma brucei
1.1.1.44 5-phospho-D-arabinonamide
-
 Ovis aries
1.1.1.44 5-phospho-D-arabinonamide
-
 Trypanosoma brucei
1.1.1.44 5-phospho-D-arabinonate
-
 Ovis aries
1.1.1.44 5-phospho-D-arabinonate
-
 Trypanosoma brucei
1.1.1.44 5-phospho-D-arabinonhydrazide
-
 Ovis aries
1.1.1.44 5-phospho-D-arabinonhydrazide
-
 Trypanosoma brucei
1.1.1.44 5-phospho-D-arabinono-1,4-lactone
-
 Ovis aries
1.1.1.44 5-phospho-D-arabinono-1,4-lactone
-
 Trypanosoma brucei
1.1.1.44 5-phospho-D-arabinonohydroxamic acid
-
 Ovis aries
1.1.1.44 5-phospho-D-arabinonohydroxamic acid
-
 Trypanosoma brucei
1.1.1.44 5-phospho-D-arabinose
-
 Ovis aries
1.1.1.44 5-phospho-D-arabinose
-
 Trypanosoma brucei
1.1.1.44 5-phospho-D-ribonate
-
 Ovis aries
1.1.1.44 5-phospho-D-ribonate
-
 Trypanosoma brucei
1.1.1.44 6-deoxy-6-phosphono-D-gluconate
-
 Ovis aries
1.1.1.44 6-deoxy-6-phosphono-D-gluconate
-
 Trypanosoma brucei
1.1.1.44 6-phospho-D-galactonate
-
 Ovis aries
1.1.1.44 6-phospho-D-galactonate
-
 Trypanosoma brucei
1.1.1.44 6-phosphono-D-mannonate competitive Ovis aries
1.1.1.44 6-phosphono-D-mannonate competitive Trypanosoma brucei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.0048
-
 6,7-dideoxy-7-phosphono-D-glucoheptonate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.0053
-
 6-phosphono-D-gluconate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.011
-
 6,7-dideoxy-7-phosphono-D-glucoheptonate pH 8.0, 20°C Ovis aries
1.1.1.44 0.03
-
 6-phosphono-D-gluconate pH 8.0, 20°C Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Ovis aries P00349
-
-
1.1.1.44 Trypanosoma brucei P31072
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44 recombinant from Escherichia coli Trypanosoma brucei

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 liver
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 3-keto-6-phospho-D-gluconate via 1,2-enediol intermediate Ovis aries D-ribulose 5-phosphate + CO2
-
 ?
1.1.1.44 3-keto-6-phospho-D-gluconate via 1,2-enediol intermediate Trypanosoma brucei D-ribulose 5-phosphate + CO2
-
 ?
1.1.1.44 6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
-
 Ovis aries ?
-
 ?
1.1.1.44 6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
-
 Trypanosoma brucei ?
-
 ?
1.1.1.44 6-phospho-D-gluconate + NADP+ overall reaction Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
1.1.1.44 6-phospho-D-gluconate + NADP+ overall reaction Trypanosoma brucei D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Ovis aries 3-keto-6-phospho-D-gluconate + NADPH + H+
-
 ?
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Trypanosoma brucei 3-keto-6-phospho-D-gluconate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.44 6-phosphogluconate dehydrogenase
-
 Ovis aries
1.1.1.44 6-phosphogluconate dehydrogenase
-
 Trypanosoma brucei
1.1.1.44 6PGDH
-
 Ovis aries
1.1.1.44 6PGDH
-
 Trypanosoma brucei

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.44 20
-
 assay at Ovis aries
1.1.1.44 20
-
 assay at Trypanosoma brucei

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.44 0.53
-
 6,7-dideoxy-7-phosphono-D-glucoheptonate pH 8.0, 20°C Ovis aries
1.1.1.44 1.4
-
 6,7-dideoxy-7-phosphono-D-glucoheptonate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 9
-
 6-phosphono-D-gluconate pH 8.0, 20°C Ovis aries
1.1.1.44 31.8
-
 6-phosphono-D-gluconate pH 8.0, 20°C Trypanosoma brucei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.44 8
-
 assay at Ovis aries
1.1.1.44 8
-
 assay at Trypanosoma brucei

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NADP+
-
 Ovis aries
1.1.1.44 NADP+
-
 Trypanosoma brucei

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.44 0.00013
-
 4-phospho-D-erythronate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.00095
-
 5-phospho-D-ribonate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.0013
-
 6-deoxy-6-phosphono-D-gluconate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.0034
-
 5-phospho-D-arabinonate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.0044
-
 2-deoxy-6-phosphono-D-gluconate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.0056
-
 5-phospho-D-arabinonamide pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.0058
-
 5-phospho-D-arabinonohydroxamic acid pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.007
-
 5-deoxy-5-phosphonoD-arabinonate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.011
-
 4-phospho-D-erythronate pH 8.0, 20°C Ovis aries
1.1.1.44 0.011
-
 5-phospho-D-arabinono-1,4-lactone pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.0212
-
 5,6-dideoxy-6-phosphono-D-arabino-hexonate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.025
-
 5-phospho-D-arabinose pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.0267
-
 5-phospho-D-arabinonhydrazide pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.0358
-
 6-deoxy-6-phosphono-D-gluconate pH 8.0, 20°C Ovis aries
1.1.1.44 0.067
-
 5-phospho-D-ribonate pH 8.0, 20°C Ovis aries
1.1.1.44 0.0803
-
 5-phospho-D-arabinonamide pH 8.0, 20°C Ovis aries
1.1.1.44 0.109
-
 5-phospho-D-arabinonate pH 8.0, 20°C Ovis aries
1.1.1.44 0.122
-
 1,5-diphospho-ribitol pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.128
-
 5-phospho-D-arabinonhydrazide pH 8.0, 20°C Ovis aries
1.1.1.44 0.135
-
 6-phosphono-D-mannonate pH 8.0, 20°C Ovis aries
1.1.1.44 0.147
-
 5-phospho-D-arabinono-1,4-lactone pH 8.0, 20°C Ovis aries
1.1.1.44 0.175
-
 4-phospho-D-erythrose pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.19
-
 6-phospho-D-galactonate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.274
-
 1,5-diphospho-D-ribulose pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 0.307
-
 5-phospho-D-arabinonohydroxamic acid pH 8.0, 20°C Ovis aries
1.1.1.44 0.433
-
 5-deoxy-5-phosphonoD-arabinonate pH 8.0, 20°C Ovis aries
1.1.1.44 0.5
-
 1,5-diphospho-ribitol pH 8.0, 20°C Ovis aries
1.1.1.44 0.565
-
 6-phospho-D-galactonate pH 8.0, 20°C Ovis aries
1.1.1.44 0.71
-
 5-phospho-D-arabinose pH 8.0, 20°C Ovis aries
1.1.1.44 0.77
-
 2-deoxy-6-phosphono-D-gluconate pH 8.0, 20°C Ovis aries
1.1.1.44 0.8
-
 6-phosphono-D-mannonate pH 8.0, 20°C Trypanosoma brucei
1.1.1.44 1
-
 5,6-dideoxy-6-phosphono-D-arabino-hexonate pH 8.0, 20°C Ovis aries
1.1.1.44 1
-
 1,5-diphospho-D-ribulose pH 8.0, 20°C Ovis aries
1.1.1.44 1.59
-
 4-phospho-D-erythrose pH 8.0, 20°C Ovis aries