Literature summary extracted from

Nagaoka, M.; Shiraishi, T.; Furuhata, K.; Uda, Y.
Effects of inorganic anions on the activation of acid sialidases (2003), Biol. Pharm. Bull., 26, 295-298.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.2.1.18	additional information	the enzyme is activated at 37°C and acidic pH, activation is dependent on time, pH and temperature, activation is inhibited by amastatin	Homo sapiens
3.2.1.18	additional information	the enzyme is activated at 37°C and acidic pH, activation is dependent on time, pH and temperature, activation is not inhibited by amastatin	Sus scrofa

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.2.1.18	Br-	activates	Homo sapiens
3.2.1.18	Br-	activates	Sus scrofa
3.2.1.18	Cl-	activates up to 1 M	Homo sapiens
3.2.1.18	Cl-	activates up to 100 mM, above 100 mM chloride inhibits the enzyme	Sus scrofa
3.2.1.18	additional information	not affected by nitrate, sulfate, sulfite, and disulfite ions	Sus scrofa
3.2.1.18	NO3-	activates	Homo sapiens
3.2.1.18	S2O42-	activates	Homo sapiens
3.2.1.18	SO32-	activates	Homo sapiens
3.2.1.18	SO42-	activates	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.2.1.18	Homo sapiens	-	-	-
3.2.1.18	Sus scrofa	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.2.1.18	partial	Sus scrofa

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.2.1.18	liver	-	Sus scrofa	-
3.2.1.18	placenta	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.2.1.18	acid sialidase	-	Homo sapiens
3.2.1.18	acid sialidase	-	Sus scrofa

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Release 2023.1 (January 2023)