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Literature summary extracted from

  • Schnackerz, K.D.; Dobritzsch, D.; Lindqvist, Y.; Cook, P.F.
    Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters (2004), Biochim. Biophys. Acta, 1701, 61-74.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.2 expression in Escherichia coli Sus scrofa

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.2 crystals diffract to 1.9 A Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.2 2,6-Dihydroxypyridine competitive vs. uracil Sus scrofa
1.3.1.2 5-Ethynyluracil mechanism-based inhibition Bos taurus
1.3.1.2 5-Iodo-uracil mechanism-based inhibition Bos taurus
1.3.1.2 5-Iodo-uracil mechanism-based inactivator Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.2 cytosol
-
Homo sapiens 5829
-
1.3.1.2 cytosol
-
Rattus norvegicus 5829
-
1.3.1.2 cytosol
-
Sus scrofa 5829
-
1.3.1.2 cytosol
-
Bos taurus 5829
-
1.3.1.2 cytosol
-
Cupriavidus necator 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.1.2 Iron each subunit contains 16 nonheme-irons in 4 [4Fe-4S] clusters Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.2 220000
-
-
Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.2 5,6-dihydrouracil + NADP+ Homo sapiens first and rate-limiting enzyme in the three-step pathway for the degradation of uracil uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+ Rattus norvegicus first and rate-limiting enzyme in the three-step pathway for the degradation of uracil uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+ Sus scrofa first and rate-limiting enzyme in the three-step pathway for the degradation of uracil uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+ Bos taurus first and rate-limiting enzyme in the three-step pathway for the degradation of uracil uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+ Cupriavidus necator first and rate-limiting enzyme in the three-step pathway for the degradation of uracil uracil + NADPH
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Bos taurus
-
-
-
1.3.1.2 Cupriavidus necator
-
-
-
1.3.1.2 Homo sapiens
-
-
-
1.3.1.2 Rattus norvegicus
-
-
-
1.3.1.2 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.2
-
Homo sapiens
1.3.1.2
-
Rattus norvegicus
1.3.1.2
-
Sus scrofa
1.3.1.2
-
Bos taurus
1.3.1.2
-
Cupriavidus necator

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.2 liver
-
Homo sapiens
-
1.3.1.2 liver
-
Rattus norvegicus
-
1.3.1.2 liver
-
Sus scrofa
-
1.3.1.2 liver
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 5,6-dihydrouracil + NADP+
-
Homo sapiens uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+
-
Rattus norvegicus uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+
-
Sus scrofa uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+
-
Bos taurus uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+
-
Cupriavidus necator uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+ first and rate-limiting enzyme in the three-step pathway for the degradation of uracil Homo sapiens uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+ first and rate-limiting enzyme in the three-step pathway for the degradation of uracil Rattus norvegicus uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+ first and rate-limiting enzyme in the three-step pathway for the degradation of uracil Sus scrofa uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+ first and rate-limiting enzyme in the three-step pathway for the degradation of uracil Bos taurus uracil + NADPH
-
?
1.3.1.2 5,6-dihydrouracil + NADP+ first and rate-limiting enzyme in the three-step pathway for the degradation of uracil Cupriavidus necator uracil + NADPH
-
?

Subunits

EC Number Subunits Comment Organism
1.3.1.2 dimer
-
Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
1.3.1.2 DPD
-
Homo sapiens
1.3.1.2 DPD
-
Rattus norvegicus
1.3.1.2 DPD
-
Sus scrofa
1.3.1.2 DPD
-
Bos taurus
1.3.1.2 DPD
-
Cupriavidus necator

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 FAD 1 FAD per subunit Sus scrofa
1.3.1.2 FMN 1 FMN per subunit Sus scrofa
1.3.1.2 NADP+
-
Homo sapiens
1.3.1.2 NADP+
-
Rattus norvegicus
1.3.1.2 NADP+
-
Sus scrofa
1.3.1.2 NADP+
-
Bos taurus
1.3.1.2 NADP+
-
Cupriavidus necator