EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.1.2 | expression in Escherichia coli | Sus scrofa |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.3.1.2 | crystals diffract to 1.9 A | Sus scrofa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.2 | 2,6-Dihydroxypyridine | competitive vs. uracil | Sus scrofa | |
1.3.1.2 | 5-Ethynyluracil | mechanism-based inhibition | Bos taurus | |
1.3.1.2 | 5-Iodo-uracil | mechanism-based inhibition | Bos taurus | |
1.3.1.2 | 5-Iodo-uracil | mechanism-based inactivator | Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.1.2 | cytosol | - |
Homo sapiens | 5829 | - |
1.3.1.2 | cytosol | - |
Rattus norvegicus | 5829 | - |
1.3.1.2 | cytosol | - |
Sus scrofa | 5829 | - |
1.3.1.2 | cytosol | - |
Bos taurus | 5829 | - |
1.3.1.2 | cytosol | - |
Cupriavidus necator | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.2 | Iron | each subunit contains 16 nonheme-irons in 4 [4Fe-4S] clusters | Sus scrofa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.3.1.2 | 220000 | - |
- |
Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.2 | 5,6-dihydrouracil + NADP+ | Homo sapiens | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | Rattus norvegicus | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | Sus scrofa | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | Bos taurus | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | Cupriavidus necator | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.2 | Bos taurus | - |
- |
- |
1.3.1.2 | Cupriavidus necator | - |
- |
- |
1.3.1.2 | Homo sapiens | - |
- |
- |
1.3.1.2 | Rattus norvegicus | - |
- |
- |
1.3.1.2 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.3.1.2 | - |
Homo sapiens |
1.3.1.2 | - |
Rattus norvegicus |
1.3.1.2 | - |
Sus scrofa |
1.3.1.2 | - |
Bos taurus |
1.3.1.2 | - |
Cupriavidus necator |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.1.2 | liver | - |
Homo sapiens | - |
1.3.1.2 | liver | - |
Rattus norvegicus | - |
1.3.1.2 | liver | - |
Sus scrofa | - |
1.3.1.2 | liver | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.2 | 5,6-dihydrouracil + NADP+ | - |
Homo sapiens | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | - |
Rattus norvegicus | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | - |
Sus scrofa | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | - |
Bos taurus | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | - |
Cupriavidus necator | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Homo sapiens | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Rattus norvegicus | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Sus scrofa | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Bos taurus | uracil + NADPH | - |
? | |
1.3.1.2 | 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Cupriavidus necator | uracil + NADPH | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.3.1.2 | dimer | - |
Sus scrofa |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.1.2 | DPD | - |
Homo sapiens |
1.3.1.2 | DPD | - |
Rattus norvegicus |
1.3.1.2 | DPD | - |
Sus scrofa |
1.3.1.2 | DPD | - |
Bos taurus |
1.3.1.2 | DPD | - |
Cupriavidus necator |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.2 | FAD | 1 FAD per subunit | Sus scrofa | |
1.3.1.2 | FMN | 1 FMN per subunit | Sus scrofa | |
1.3.1.2 | NADP+ | - |
Homo sapiens | |
1.3.1.2 | NADP+ | - |
Rattus norvegicus | |
1.3.1.2 | NADP+ | - |
Sus scrofa | |
1.3.1.2 | NADP+ | - |
Bos taurus | |
1.3.1.2 | NADP+ | - |
Cupriavidus necator |