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Literature summary extracted from

  • Lin, S.; Gasmi, L.; Xie, Y.; Ying, K.; Gu, S.; Wang, Z.; Jin, H.; Chao, Y.; Wu, C.; Zhou, Z.; Tang, R.; Mao, Y.; McLennan, A.G.
    Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose) (2001), Biochim. Biophys. Acta, 1594, 127-135.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.13 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.13 F-
-
Homo sapiens
3.6.1.13 N-acetyl-p-benzoquinoneimine 1 mM, almost complete inhibition of activity towards ADPribose. The inhibitor is a useful tool for distinguishing the specific ADP-ribose diphosphatase from the less specific ADP-sugar diphosphatases Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.13 0.18
-
ADPribose
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.13 Mg2+ activates Homo sapiens
3.6.1.13 Mn2+ activates Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.13 47000
-
x * 47000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.13 Homo sapiens Q9BW91 Nudix motif
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.13 ADPribose + H2O
-
Homo sapiens AMP + D-ribose 5-phosphate
-
?
3.6.1.13 IDPribose + H2O 77% of the activity with ADPribose Homo sapiens IMP + D-ribose 5-phosphate
-
?

Subunits

EC Number Subunits Comment Organism
3.6.1.13 ? x * 47000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.6.1.13 NUDT9alpha protein
-
Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6.1.13 8
-
ADPribose
-
Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.13 8 10
-
Homo sapiens