BRENDA - Enzyme Database

Direct evidence for expression of type II flavoprotein subunit in human complex II (succinate-ubiquinone reductase)

Tomitsuka, E.; Goto, Y.; Taniwaki, M.; Kita, K.; Biochem. Biophys. Res. Commun. 311, 774-779 (2003)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
1.3.5.1
cloning of 2 distinct cDNAs of flavoprotein subunit of SQR
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.3.5.1
atpenin A5
0.0000042 mM, 50% inhibition
Homo sapiens
1.3.5.1
malonate
0.18 mM, 50% inhibition
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.3.5.1
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.3.5.1
succinate + ubiquinone
Homo sapiens
-
fumarate + ubiquinol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.3.5.1
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.3.5.1
brain
expression of 2 distinct flavoprotein subunits
Homo sapiens
-
1.3.5.1
heart
expression of 2 distinct flavoprotein subunits
Homo sapiens
-
1.3.5.1
HT-29 cell
-
Homo sapiens
-
1.3.5.1
kidney
expression of 2 distinct flavoprotein subunits
Homo sapiens
-
1.3.5.1
liver
; expression of 2 distinct flavoprotein subunits
Homo sapiens
-
1.3.5.1
RAJI cell
express only type II Fp subunit of SQR complex
Homo sapiens
-
1.3.5.1
skeletal muscle
expression of 2 distinct flavoprotein subunits
Homo sapiens
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
1.3.5.1
0.024
-
SQR activity in raji cells
Homo sapiens
1.3.5.1
0.039
-
SQR activity in HT-29 cells
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.3.5.1
succinate + ubiquinone
-
654444
Homo sapiens
fumarate + ubiquinol
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.3.5.1
cloning of 2 distinct cDNAs of flavoprotein subunit of SQR
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.3.5.1
atpenin A5
0.0000042 mM, 50% inhibition
Homo sapiens
1.3.5.1
malonate
0.18 mM, 50% inhibition
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.3.5.1
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.3.5.1
succinate + ubiquinone
Homo sapiens
-
fumarate + ubiquinol
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.3.5.1
brain
expression of 2 distinct flavoprotein subunits
Homo sapiens
-
1.3.5.1
heart
expression of 2 distinct flavoprotein subunits
Homo sapiens
-
1.3.5.1
HT-29 cell
-
Homo sapiens
-
1.3.5.1
kidney
expression of 2 distinct flavoprotein subunits
Homo sapiens
-
1.3.5.1
liver
; expression of 2 distinct flavoprotein subunits
Homo sapiens
-
1.3.5.1
RAJI cell
express only type II Fp subunit of SQR complex
Homo sapiens
-
1.3.5.1
skeletal muscle
expression of 2 distinct flavoprotein subunits
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
1.3.5.1
0.024
-
SQR activity in raji cells
Homo sapiens
1.3.5.1
0.039
-
SQR activity in HT-29 cells
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.3.5.1
succinate + ubiquinone
-
654444
Homo sapiens
fumarate + ubiquinol
-
-
-
?