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Literature summary extracted from

  • Karlsson, T.; Vahlquist, A.; Kedishvili, N.; Torma, H.
    13-cis-retinoic acid competitively inhibits 3alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands? (2003), Biochem. Biophys. Res. Commun., 303, 273-278.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.105 13-cis-retinoic acid
-
 Homo sapiens
1.1.1.105 3,4-didehydroretinoic acid
-
 Homo sapiens
1.1.1.105 3,4-didehydroretinol
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.105 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.105 Homo sapiens
-
 recombinant enzyme expressed in Sf9 cells
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.105 3,4-didehydroretinol + NAD+ 60% of the efficiency against all-trans-retinol Homo sapiens 3,4-didehydroretinal + NADH
-
 ?
1.1.1.105 5alpha-androstan-3alpha-ol-17-one + NAD+
-
 Homo sapiens ? + NADH
-
 ?
1.1.1.105 all-trans-retinol + NAD+
-
 Homo sapiens all-trans-retinal + NADH
-
 ?
1.1.1.105 androsterone + NAD+
-
 Homo sapiens ? + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.105 NAD+
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.105 0.00021
-
 13-cis-retinoic acid pH 7.3, 37°C, substrate 3alpha-adiol Homo sapiens
1.1.1.105 0.0011
-
 13-cis-retinoic acid pH 7.3, 37°C, substrate androsterone Homo sapiens
1.1.1.105 0.0022
-
 3,4-didehydroretinol pH 7.3, 37°C, substrate 3alpha-adiol Homo sapiens
1.1.1.105 0.0025
-
 3,4-didehydroretinol pH 7.3, 37°C, substrate androsterone Homo sapiens
1.1.1.105 0.0035
-
 3,4-didehydroretinoic acid pH 7.3, 37°C, substrate androsterone Homo sapiens
1.1.1.105 0.0069
-
 3,4-didehydroretinoic acid pH 7.3, 37°C, substrate 3alpha-adiol Homo sapiens