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Literature summary extracted from

  • Martras, S.; Alvarez, R.; Gallego, O.; Dominguez, M.; de Lera, A.R.; Farres, J.; Pares, X.
    Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80 (2004), Arch. Biochem. Biophys., 430, 210-217.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.1 Tween 80 competitive, stabilizes the retinoid compounds, elevates the Km values of the substrates, most effective at 0.1% w/v Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.1 0.004
-
 4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
1.1.1.1 0.011
-
 all-trans-retinal pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
1.1.1.1 0.011
-
 4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.012
-
 all-trans-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.015
-
 4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 0.017
-
 4-oxo-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 0.023
-
 all-trans-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 0.024
-
 3,4-dihydro-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.025
-
 4-oxo-retinal pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
1.1.1.1 0.025
-
 3,4-dihydro-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.026
-
 3,4-dihydro-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 0.027
-
 4-oxo-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.028
-
 3,4-dihydro-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 0.03
-
 all-trans-retinol pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
1.1.1.1 0.033
-
 all-trans-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.034
-
 all-trans-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 3,4-dihydro-retinol + NAD+
-
 Homo sapiens 3,4-dihydro-retinal
-
 r
1.1.1.1 4-hydroxy-retinol + NAD+
-
 Homo sapiens 4-oxo-retinal + NADH
-
 r
1.1.1.1 all-trans-retinol + NAD+
-
 Homo sapiens all-trans-retinal + NADH
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.1 25
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.1 0.018
-
 all-trans-retinal pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
1.1.1.1 0.028
-
 all-trans-retinol pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
1.1.1.1 0.088
-
 3,4-dihydro-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.092
-
 4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
1.1.1.1 0.167
-
 4-oxo-retinal pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
1.1.1.1 0.22
-
 3,4-dihydro-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.25
-
 all-trans-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.55
-
 all-trans-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 0.9
-
 all-trans-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 1.22
-
 3,4-dihydro-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 1.83
-
 all-trans-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 2.5
-
 3,4-dihydro-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 2.83
-
 4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 7.83
-
 4-oxo-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
1.1.1.1 20
-
 4-oxo-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.1.1.1 34.2
-
 4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.1 7.5
-
 assay at Homo sapiens