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Literature summary extracted from

  • Panoutsopoulos, G.I.; Beedham, C.
    Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes (2004), Acta Biochim. Pol., 51, 649-663.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.3.1 3,4-Dihydroxybenzaldehyde 0.01 mM, 50% and 76% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM, 87% inhibition of 2-hydroxy-benzaldehyde oxidation Cavia porcellus
1.2.3.1 3,4-dimethoxy-2-phenylethylamine 0.1 mM and 1 mM, 48% and 100% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
1.2.3.1 3-Hydroxy-4-methoxybenzaldehyde 0.1 mM, 87% and 85% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM, 87% inhibition of 2-hydroxy-benzaldehyde oxidation Cavia porcellus
1.2.3.1 4-hydroxy-3-methoxy-2-phenylethylamine 0.1 mM and 1 mM, 21% and 55% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
1.2.3.1 catechol 0.1 mM and 1 mM, 64% and 98% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
1.2.3.1 dopamine 0.1 mM, 80% and 93% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM and 1 mM, 59% and 100% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
1.2.3.1 L-Dopa 0.1 mM and 1 mM, 39% and 94% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
1.2.3.1 noradrenaline 0.1 mM, 51% and 95% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM and 1 mM, 90% and 100% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
1.17.3.2 dopamine 23% inhibition at 1 mM and at 0.1 mM Bos taurus
1.17.3.2 noradrenaline 15% inhibition at 0.1 mM, 30% inhibition at 1 mM Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.3.1 0.004
-
 2-Methoxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
1.2.3.1 0.005
-
 3-Hydroxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
1.2.3.1 0.008
-
 4-hydroxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
1.2.3.1 0.019
-
 benzaldehyde 37°C, pH 7.0 Cavia porcellus
1.2.3.1 0.019
-
 3,4-dimethoxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
1.2.3.1 0.02
-
 3-Methoxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
1.2.3.1 0.02
-
 2-Hydroxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
1.2.3.1 0.029
-
 3-Methoxy-4-hydroxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
1.17.3.2 0.039
-
 3,4-Dihydroxybenzaldehyde
-
 Bos taurus
1.17.3.2 0.12
-
 4-hydroxy-3-methoxybenzaldehyde
-
 Bos taurus
1.17.3.2 0.17
-
 4-hydroxybenzaldehyde
-
 Bos taurus
1.17.3.2 0.17
-
 4-methoxybenzaldehyde
-
 Bos taurus
1.17.3.2 0.17
-
 (carboxymethyl)cellulose with endohydrolysed (1->4)-beta-D-glucosidic linkages
-
 Bos taurus
1.17.3.2 0.18
-
 3-Hydroxybenzaldehyde
-
 Bos taurus
1.17.3.2 0.18
-
 3-Hydroxy-4-methoxybenzaldehyde
-
 Bos taurus
1.17.3.2 0.19
-
 2-Methoxybenzaldehyde
-
 Bos taurus
1.17.3.2 0.19
-
 2-Hydroxybenzaldehyde
-
 Bos taurus
1.17.3.2 0.3
-
 benzaldehyde
-
 Bos taurus
1.17.3.2 0.68
-
 3,4-dimethoxybenzaldehyde
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.2.3.1 Cavia porcellus
-
 Dunkin-Hartley guinea pigs
-
1.17.3.2 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.3.1 ammonium sulfate precipitation Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.1 liver
-
 Cavia porcellus
-
1.17.3.2 milk
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.3.1 2-hydroxybenzaldehyde + H2O + O2
-
 Cavia porcellus 2-hydroxybenzoate + H2O2
-
 ?
1.2.3.1 2-methoxybenzaldehyde + H2O + O2
-
 Cavia porcellus 2-methoxybenzoate + H2O2
-
 ?
1.2.3.1 3,4-dimethoxybenzaldehyde + H2O + O2
-
 Cavia porcellus 3,4-dimethoxybenzoate + H2O2
-
 ?
1.2.3.1 3-hydroxybenzaldehyde + H2O + O2
-
 Cavia porcellus 3-hydroxybenzoate + H2O2
-
 ?
1.2.3.1 3-methoxy-4-hydroxybenzaldehyde + H2O + O2
-
 Cavia porcellus 3-methoxy-4-hydroxybenzoate + H2O2
-
 ?
1.2.3.1 3-methoxybenzaldehyde + H2O + O2
-
 Cavia porcellus 3-methoxybenzoate + H2O2
-
 ?
1.2.3.1 4-hydroxybenzaldehyde + H2O + O2
-
 Cavia porcellus 4-hydroxybenzoate + H2O2
-
 ?
1.2.3.1 4-methoxybenzaldehyde + H2O + O2
-
 Cavia porcellus 4-methoxybenzoate + H2O2
-
 ?
1.2.3.1 benzaldehyde + H2O + O2
-
 Cavia porcellus benzoate + H2O2
-
 ?
1.2.3.1 N-methylphthalazinium + O2 + H2O
-
 Cavia porcellus ?
-
 ?
1.2.3.1 phenanthridine + O2 + H2O
-
 Cavia porcellus ?
-
 ?
1.17.3.2 (carboxymethyl)cellulose with endohydrolysed (1->4)-beta-D-glucosidic linkages + H2O + O2
-
 Bos taurus ?
-
 r
1.17.3.2 2-hydroxybenzaldehyde + H2O + O2
-
 Bos taurus 2-hydroxybenzoate + H2O2
-
 ?
1.17.3.2 2-methoxybenzaldehyde + H2O + O2
-
 Bos taurus 2-methoxybenzoate + H2O2
-
 ?
1.17.3.2 3,4-dihydroxybenzaldehyde + H2O + O2
-
 Bos taurus 3,4-dihydroxybenzoate + H2O2
-
 ?
1.17.3.2 3,4-dimethoxybenzaldehyde + H2O + O2
-
 Bos taurus 3,4-dimethoxybenzoate + H2O2
-
 ?
1.17.3.2 3-hydroxy-4-methoxybenzaldehyde + H2O + O2
-
 Bos taurus 3-hydroxy-4-methoxybenzoate + H2O2
-
 ?
1.17.3.2 3-hydroxybenzaldehyde + H2O + O2
-
 Bos taurus 3-hydroxybenzoate + H2O2
-
 ?
1.17.3.2 3-methoxybenzaldehyde + H2O + O2
-
 Bos taurus 3-methoxybenzoate + H2O2
-
 ?
1.17.3.2 4-hydroxy-3-methoxybenzaldehyde + H2O + O2
-
 Bos taurus 4-hydroxy-3-methoxybenzoate + H2O2
-
 ?
1.17.3.2 4-hydroxybenzaldehyde + H2O + O2
-
 Bos taurus 4-hydroxybenzoate + H2O2
-
 ?
1.17.3.2 4-methoxybenzaldehyde + H2O + O2
-
 Bos taurus 4-methoxybenzoate + H2O2
-
 ?
1.17.3.2 benzaldehyde + H2O + O2
-
 Bos taurus benzoate + H2O2
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.3.1 0.00016
-
 3,4-Dihydroxybenzaldehyde 37°C, pH 7.0, inhibition of 2-hydroxybenzaldehyde oxidation Cavia porcellus
1.2.3.1 0.00066
-
 3-Hydroxy-4-methoxybenzaldehyde 37°C, pH 7.0, inhibition of 2-hydroxybenzaldehyde oxidation Cavia porcellus