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Literature summary extracted from

  • Tamura, T.; Tamura, N.; Cejka, Z.; Hegerl, R.; Lottspeich, F.; Baumeister, W.
    Tricorn protease--the core of a modular proteolytic system (1996), Science, 274, 1385-1389.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B34 tosyl-L-phenylalanine chloromethyl ketone
-
 Thermoplasma acidophilum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.B34 120000
-
 6 * 120000, the hexameric toroid can assemble further into a capsid structure. Tricorn protease appears to act as a core of a proteolytic system, when it interacts with several smaller proteins, it displays multicatalytic activities, SDS-PAGE Thermoplasma acidophilum
3.4.21.B34 720000
-
 gel filtration Thermoplasma acidophilum

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B34 Thermoplasma acidophilum P96086
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B34
-
 Thermoplasma acidophilum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B34 Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum ?
-
 ?
3.4.21.B34 benzoyl-Val-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum ?
-
 ?
3.4.21.B34 benzyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum ?
-
 ?
3.4.21.B34 benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum ?
-
 ?
3.4.21.B34 additional information no cleavage of succinyl-Leu-Tyr-7-amido-4-methylcoumarin, succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin, succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin and benzyloxycarbonyl-Gly-Gly-Leu-7-amido-4-methylcoumarin Thermoplasma acidophilum ?
-
 ?
3.4.21.B34 tert-butyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.B34 hexamer 6 * 120000, the hexameric toroid can assemble further into a capsid structure. Tricorn protease appears to act as a core of a proteolytic system, when it interacts with several smaller proteins, it displays multicatalytic activities, SDS-PAGE Thermoplasma acidophilum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.B34 65
-
-
 Thermoplasma acidophilum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.B34 8.5 8.8
-
 Thermoplasma acidophilum

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.21.B34 Thermoplasma acidophilum calculation from nucleotide sequence
-
 5.8