BRENDA - Enzyme Database

Inhibition of Klenow DNA polymerase and poly(A)-specific ribonuclease by aminoglycosides

Ren, Y.G.; Martinez, J.; Kirsebom, L.A.; Virtanen, A.; RNA 8, 1393-1400 (2002)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.13.4
kanamycin A
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
3.1.13.4
kanamycin B
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
3.1.13.4
lividomycin
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
3.1.13.4
additional information
model of inhibition mechanism for aminoglycosides, competition with divalent metal ions
Bos taurus
3.1.13.4
neomycin B
50% inhibition by high nanomolar concentrations, inhibition is pH-dependent, competition with divalent metal ions
Bos taurus
3.1.13.4
paromomycin
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
3.1.13.4
tobramycin
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.13.4
Bos taurus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.13.4
thymus
-
Bos taurus
-
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
3.1.13.4
0.0004
-
neomycin B
pH 7.0
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.13.4
kanamycin A
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
3.1.13.4
kanamycin B
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
3.1.13.4
lividomycin
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
3.1.13.4
additional information
model of inhibition mechanism for aminoglycosides, competition with divalent metal ions
Bos taurus
3.1.13.4
neomycin B
50% inhibition by high nanomolar concentrations, inhibition is pH-dependent, competition with divalent metal ions
Bos taurus
3.1.13.4
paromomycin
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
3.1.13.4
tobramycin
50% inhibition by high nanomolar concentrations, competition with divalent metal ions
Bos taurus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
3.1.13.4
0.0004
-
neomycin B
pH 7.0
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.13.4
thymus
-
Bos taurus
-