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Literature summary extracted from

  • Ren, Y.G.; Martinez, J.; Kirsebom, L.A.; Virtanen, A.
    Inhibition of Klenow DNA polymerase and poly(A)-specific ribonuclease by aminoglycosides (2002), RNA, 8, 1393-1400.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.13.4 kanamycin A 50% inhibition by high nanomolar concentrations, competition with divalent metal ions Bos taurus
3.1.13.4 kanamycin B 50% inhibition by high nanomolar concentrations, competition with divalent metal ions Bos taurus
3.1.13.4 lividomycin 50% inhibition by high nanomolar concentrations, competition with divalent metal ions Bos taurus
3.1.13.4 additional information model of inhibition mechanism for aminoglycosides, competition with divalent metal ions Bos taurus
3.1.13.4 neomycin B 50% inhibition by high nanomolar concentrations, inhibition is pH-dependent, competition with divalent metal ions Bos taurus
3.1.13.4 paromomycin 50% inhibition by high nanomolar concentrations, competition with divalent metal ions Bos taurus
3.1.13.4 tobramycin 50% inhibition by high nanomolar concentrations, competition with divalent metal ions Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.13.4 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.13.4 thymus
-
 Bos taurus
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.13.4 0.0004
-
 neomycin B pH 7.0 Bos taurus