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Literature summary extracted from

  • Zuegg, J.; Gruber, K.; Gugganig, M.; Wagner, U.G.; Kratky, C.
    Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis (1999), Protein Sci., 8, 1990-2000.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.2.47 enzyme in complex with acetone, hexafluoroacetone, trichloroacetaldehyde or rhodanine, hanging-drop vapour diffusion method, space group C222(1) Hevea brasiliensis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.47 acetone
-
 Hevea brasiliensis
4.1.2.47 hexafluoroacetone
-
 Hevea brasiliensis
4.1.2.47 rhodanide very strong competitive inhibitor Hevea brasiliensis
4.1.2.47 trichloracetaldehyde
-
 Hevea brasiliensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.47 2-hydroxy-2-methylpropanenitrile Hevea brasiliensis release of HCN serves as a defense against herbivores and microbial attack of the plant acetone + HCN
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.47 Hevea brasiliensis
-
 tropical rubber tree
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.47 2-hydroxy-2-methylpropanenitrile release of HCN serves as a defense against herbivores and microbial attack of the plant Hevea brasiliensis acetone + HCN
-
 ?
4.1.2.47 2-hydroxyisobutyronitrile
-
 Hevea brasiliensis HCN + acetone
-
 ?
4.1.2.47 mandelonitrile racemic Hevea brasiliensis HCN + benzaldehyde
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.47 Hb-HNL
-
 Hevea brasiliensis
4.1.2.47 HNL
-
 Hevea brasiliensis