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Literature summary extracted from
- Proton-motive force stimulates the proteolytic activity of FtsH, a membrane-bound ATP-dependent protease in Escherichia coli (2002), Proc. Natl. Acad. Sci. USA, 99, 8066-8071.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B17 | additional information | stimulation by the proton motive force through the transmembrane region | Escherichia coli | |
| 3.4.24.B17 | succinate | stimulates, antagonist of carbonyl cyanide-3-chlorophenylhydrazone | Escherichia coli |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B17 | 2,4-dinitrophenol | - |
Escherichia coli | |
| 3.4.24.B17 | carbonyl cyanide-3-chlorophenylhydrazone | antagonist of succinate | Escherichia coli | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.B17 | membrane | integral | Escherichia coli | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B17 | Zn2+ | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B17 | protein + H2O | Escherichia coli | - |
peptides | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.B17 | Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B17 | casein + H2O | - |
Escherichia coli | peptides | - |
? | |
| 3.4.24.B17 | protein + H2O | - |
Escherichia coli | peptides | - |
? | |
| 3.4.24.B17 | protein + H2O | degradation of membrane and cytoplasmic proteins | Escherichia coli | peptides | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.B17 | FtsH | - |
Escherichia coli |
| 3.4.24.B17 | M41.001 | Merops-ID | Escherichia coli |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.B17 | 37 | - |
assay at | Escherichia coli |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.B17 | 8.1 | - |
assay at | Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B17 | ATP | dependent on | Escherichia coli | |
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Release 2023.1 (January 2023)
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