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Literature summary extracted from

  • Leiper, J.; Murray-Rust, J.; McDonald, N.; Vallance, P.
    S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase (2002), Proc. Natl. Acad. Sci. USA, 99, 13527-13532.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.3.18 expression in Escherichia coli Pseudomonas aeruginosa
3.5.3.18 expression in sEnd.1 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.5.3.18 C249S C249 is predominant target for S-nitrosylation Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.18 2-(N,N-dimethylamino)-diazenolate-2-oxide i.e. DEANONOate, inhibition by S-nitrosylation, reversed by dithiothreitol Homo sapiens
3.5.3.18 2-(N,N-dimethylamino)-diazenolate-2-oxide i.e. DEANONOate, inhibition by S-nitrosylation, reversed by dithiothreitol Pseudomonas aeruginosa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.3.18 40000
-
 x * 40000, SDS-PAGE, His-tagged protein Pseudomonas aeruginosa
3.5.3.18 40000
-
 x * 40000, SDS-PAGE, Myc-tagged protein Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.18 Homo sapiens
-
-
-
3.5.3.18 Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.3.18 recombinant enzyme, partial Homo sapiens
3.5.3.18 recombinant enzyme, partial Pseudomonas aeruginosa

Renatured (Commentary)

EC Number Renatured (Comment) Organism
3.5.3.18 inhibition by 2-(N,N-dimethylamino)-diazenolate-2-oxide is reversed by dithiothreitol Homo sapiens
3.5.3.18 inhibition by 2-(N,N-dimethylamino)-diazenolate-2-oxide is reversed by dithiothreitol Pseudomonas aeruginosa

Subunits

EC Number Subunits Comment Organism
3.5.3.18 ? x * 40000, SDS-PAGE, His-tagged protein Pseudomonas aeruginosa
3.5.3.18 ? x * 40000, SDS-PAGE, Myc-tagged protein Homo sapiens