Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dinh, T.P.; Carpenter, D.; Leslie, F.M.; Freund, T.F.; Katona, I.; Sensi, S.L.; Kathuria, S.; Piomelli, D.
    Brain monoglyceride lipase participating in endocannabinoid inactivation (2002), Proc. Natl. Acad. Sci. USA, 99, 10819-10824.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.23
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 arachidonoyl trifluoromethylketone 50% inhibition at 0.0025 mM Rattus norvegicus
3.1.1.23 hexadecylsufonyl fluoride 50% inhibition at 0.0062 mM Rattus norvegicus
3.1.1.23 methyl arachidonyl fluorophosphonate 50% inhibition at 0.0008 mM Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.23 33370
-
 calculated from amino acid sequence Rattus norvegicus
3.1.1.23 35000
-
 two closely related isoforms of 35000 Da and 37000 Da, SDS-PAGE Rattus norvegicus
3.1.1.23 37000
-
 two closely related isoforms of 35000 Da and 37000 Da, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Rattus norvegicus Q8R431
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 brain
-
 Rattus norvegicus
-
3.1.1.23 cerebellum
-
 Rattus norvegicus
-
3.1.1.23 cerebral cortex
-
 Rattus norvegicus
-
3.1.1.23 hippocampus
-
 Rattus norvegicus
-
3.1.1.23 thalamus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Rattus norvegicus arachidonic acid + glycerol
-
 ?
3.1.1.23 2-monooleoylglycerol + H2O
-
 Rattus norvegicus oleic acid + glycerol
-
 r
3.1.1.23 additional information enzyme does not hydrolyze palmitoylethanolamine, enzyme preferentially hydrolyzes 2-monoglycerides Rattus norvegicus ?
-
 ?