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Literature summary extracted from

  • Beresford, P.J.; Kam, C.M.; Powers, J.C.; Lieberman, J.
    Recombinant human granzyme A binds to putative HLA-associated proteins and cleaves one of them (1997), Proc. Natl. Acad. Sci. USA, 94, 9285-9290.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.78 granzyme A expressed in Escherichia coli BL21-DE3 as a proenzyme capable of in vitro activation by enterokinase Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.78 3,4-dichloroisocoumarin weak inhibition Homo sapiens
3.4.21.78 benzamidine
-
Homo sapiens
3.4.21.78 C6H4CH2SO2-Gly-Pro(4-amidinophenylglycine)P(OPh)2
-
Homo sapiens
3.4.21.78 guanidinobenzoate
-
Homo sapiens
3.4.21.78 isocoumarin
-
Homo sapiens
3.4.21.78 p-guanidino-C6H4-COOC6H4-p-CN
-
Homo sapiens
3.4.21.78 PhNH-CONH-CiTEtOIC isocoumarinderivate, best inhibitor Homo sapiens
3.4.21.78 phosphonate
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.78 0.17
-
Boc-Trp-Arg-SBzl pH 7.5, 30°C Homo sapiens
3.4.21.78 0.177
-
Z-Arg-SBzl pH 7.5, 30°C Homo sapiens
3.4.21.78 0.767
-
Z-Lys-SBzl pH 7.5, 30°C Homo sapiens
3.4.21.78 0.887
-
Boc-Ala-Ala-Arg-SBzl pH 7.5, 30°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.78 additional information Homo sapiens most abundant protease in cytotoxic T lymphocytes, granzyme A pathway of cell-mediated cytotoxicity, produced as proenzyme, activated by the dipetidyl exopeptidase cathepsin C ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.78 Homo sapiens
-
human
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.78 benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
-
Homo sapiens benzyloxycarbonyl-Lys + phenylmethanethiol
-
?
3.4.21.78 Boc-Ala-Ala-Arg-SBzl + H2O thioester substrate, recombinant granzyme A Homo sapiens ?
-
?
3.4.21.78 Boc-Trp-Arg-SBzl + H2O thioester substrate, recombinant granzyme A Homo sapiens ?
-
?
3.4.21.78 CBZ-Lys-SBzl + H2O thioester substrate, recombinant granzyme A Homo sapiens ?
-
?
3.4.21.78 additional information most abundant protease in cytotoxic T lymphocytes, granzyme A pathway of cell-mediated cytotoxicity, produced as proenzyme, activated by the dipetidyl exopeptidase cathepsin C Homo sapiens ?
-
?
3.4.21.78 N-alpha-benzyloxycarbonyl-Arg-SBzl + H2O thioester substrate, recombinant granzyme A Homo sapiens ?
-
?
3.4.21.78 PHAPII + H2O HLA-associated protein, cleaved by the recombinant enzyme at nanomolar concentrations Homo sapiens ?
-
?

Subunits

EC Number Subunits Comment Organism
3.4.21.78 dimer only granzyme that forms a disulfide-linked homodimer Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.78 3960
-
Boc-Trp-Arg-SBzl pH 7.5, 30°C Homo sapiens
3.4.21.78 4980
-
Boc-Ala-Ala-Arg-SBzl pH 7.5, 30°C Homo sapiens
3.4.21.78 22100
-
Z-Lys-SBzl pH 7.5, 30°C Homo sapiens
3.4.21.78 22140
-
Z-Lys-SBzl pH 7.5, 30°C Homo sapiens
3.4.21.78 30360
-
Z-Arg-SBzl pH 7.5, 30°C Homo sapiens
3.4.21.78 30400
-
Z-Arg-SBzl pH 7.5, 30°C Homo sapiens