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Literature summary extracted from

  • Kihara, A.; Akiyama, Y.; Ito, K.
    FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit (1995), Proc. Natl. Acad. Sci. USA, 92, 4532-4536.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B17 expression of several mutant enzyme forms Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B17 L189W mutation ftsH102, partial complementation of temperature sensitivity of the ftsH1 mutant at 42°C but not other cols-sensitive mutants, overview Escherichia coli
3.4.24.B17 additional information defects in the ftsH gene stabilize the SecY protein, overexpression increase the degradation of SecY, enzyme deficient mutantion ftsH101 suppresses the temperature-sensitive export defect of a secY24 mutant G240D in the cytoplasmic domain of SecY by stabilizing the mutant protein Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B17 protein SecE stabilizes overexpressed SecY against proteolytic degradation by the enzyme, acts a an antagonist Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B17 protein + H2O Escherichia coli
-
 peptides
-
 ?
3.4.24.B17 protein SecY + H2O Escherichia coli quality control, the enzyme regulates the amount of SecY assembled in the mitochondrial membrane, elimination of uncomplexed SecY is important for optimum protein translocation and for the integrity of the membrane ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B17 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B17 protein + H2O
-
 Escherichia coli peptides
-
 ?
3.4.24.B17 protein SecY + H2O
-
 Escherichia coli ?
-
 ?
3.4.24.B17 protein SecY + H2O quality control, the enzyme regulates the amount of SecY assembled in the mitochondrial membrane, elimination of uncomplexed SecY is important for optimum protein translocation and for the integrity of the membrane Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B17 M41.001 Merops-ID Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.24.B17 ATP dependent on Escherichia coli