EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.11 | G protein betagamma | may be the main positive regulator of DdPLC | Dictyostelium discoideum |
EC Number | Application | Comment | Organism |
---|---|---|---|
3.1.4.11 | medicine | PLC-gamma1 may permit the progression of some tumors | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.4.11 | C1094S | NorpA mutant with slowed activation and deactivation | Drosophila sp. (in: flies) |
3.1.4.11 | additional information | DdPLC null mutant fails to aggregate at low cell densities | Dictyostelium discoideum |
3.1.4.11 | additional information | flies lacking NorpA are blind | Drosophila sp. (in: flies) |
3.1.4.11 | additional information | mutant mice lacking PLC-beta1: sudden death due to epileptic-like seizures, mutant mice lacking PLC-beta2 and PLC-beta4: phenotypes, homozygous disruption of the PLC-beta3 gene is lethal by day 2.5 of development, mutant mice with disruption of one or both copies of the PLC-gamma1 gene, homozygous mice die by embryonic day 9 | Mus musculus |
3.1.4.11 | additional information | PLC1 deletion mutant with slowed growth | Saccharomyces cerevisiae |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.11 | Ca2+ | Ca2+-dependent | Saccharomyces cerevisiae |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.4.11 | 91000 | - |
x * 91000 | Dictyostelium discoideum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.11 | additional information | Arabidopsis thaliana | AtPLC1S is involved in stress responses, AtPLC2 not | ? | - |
? | |
3.1.4.11 | additional information | Rattus norvegicus | cellular signaling | ? | - |
? | |
3.1.4.11 | additional information | Homo sapiens | cellular signaling, regulation of PLC activity | ? | - |
? | |
3.1.4.11 | additional information | Drosophila sp. (in: flies) | PLC plays a key role in photoreceptor response | ? | - |
? | |
3.1.4.11 | additional information | Mus musculus | PLC-beta1 is nessecary for the development and/or maintenance of brain inhibitory pathways, the retinal variants of PLC-beta4 function in signal processing within the retina, PLC-beta3 plays a role in the early development | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.11 | Arabidopsis thaliana | - |
AtPLC1S, AtPLC2, delta-related isotypes | - |
3.1.4.11 | Dictyostelium discoideum | - |
DdPLC, homolog to mammalian PLC-delta | - |
3.1.4.11 | Drosophila sp. (in: flies) | - |
NorpA, PLC-21 | - |
3.1.4.11 | Homo sapiens | - |
- |
- |
3.1.4.11 | Mus musculus | - |
PLC-beta | - |
3.1.4.11 | Rattus norvegicus | - |
- |
- |
3.1.4.11 | Saccharomyces cerevisiae | - |
PLC1p | - |
3.1.4.11 | Saccharomyces cerevisiae PLC1p | - |
PLC1p | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.1.4.11 | phosphoprotein | PLC-gamma1, phosphorylation sites: Tyr-771 and Tyr-783 | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.11 | astrocyte | adult brain, PLC-delta1 is concentrated in astroglial cells, much lower levels in neurons | Rattus norvegicus | - |
3.1.4.11 | brain | adult, PLC-gamma1 is diffusely distributed, expression pattern of PLC-gamma1 and PLC-delta1 during development, expression pattern of PLC-gamma2 | Rattus norvegicus | - |
3.1.4.11 | embryo | high PLC-beta3 expression in very early embryos | Mus musculus | - |
3.1.4.11 | embryo | PLC-gamma homolog, widely distributed in the embryo | Drosophila sp. (in: flies) | - |
3.1.4.11 | eye | NorpA type I, eye-specific | Drosophila sp. (in: flies) | - |
3.1.4.11 | flower | constitutive expression of AtPLC2 in vegetative and floral tissues | Arabidopsis thaliana | - |
3.1.4.11 | head | PLC-21 type I, head-specific | Drosophila sp. (in: flies) | - |
3.1.4.11 | hippocampus | PLC-beta1 is prominently expressed in hippocampal pyramidal cells | Mus musculus | - |
3.1.4.11 | leaf | AtPLC1S is concentrated in shoot and leaf | Arabidopsis thaliana | - |
3.1.4.11 | additional information | PLC-beta2 is highly expressed in cells of the immune system | Mus musculus | - |
3.1.4.11 | neuron | adult brain, much lower levels of PLC-delta1 in neurons than in astroglial cells | Rattus norvegicus | - |
3.1.4.11 | oocyte | high PLC-beta3 expression in unfertilized oocytes | Mus musculus | - |
3.1.4.11 | retina | PLC-beta4 | Mus musculus | - |
3.1.4.11 | shoot | AtPLC1S is concentrated in shoot and leaf | Arabidopsis thaliana | - |
3.1.4.11 | vegetative cell | constitutive expression of AtPLC2 in vegetative and floral tissues | Arabidopsis thaliana | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Drosophila sp. (in: flies) | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mus musculus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Arabidopsis thaliana | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Dictyostelium discoideum | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | preferred substrate | Saccharomyces cerevisiae | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | domain structures of PLC-beta, -gamma and -delta isoenzymes | Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | domain structures of PLCbeta, -gamma and -delta isoenzymes | Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | preferred substrate | Saccharomyces cerevisiae PLC1p | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
3.1.4.11 | additional information | AtPLC1S is involved in stress responses, AtPLC2 not | Arabidopsis thaliana | ? | - |
? | |
3.1.4.11 | additional information | cellular signaling | Rattus norvegicus | ? | - |
? | |
3.1.4.11 | additional information | cellular signaling, regulation of PLC activity | Homo sapiens | ? | - |
? | |
3.1.4.11 | additional information | PLC plays a key role in photoreceptor response | Drosophila sp. (in: flies) | ? | - |
? | |
3.1.4.11 | additional information | PLC-beta1 is nessecary for the development and/or maintenance of brain inhibitory pathways, the retinal variants of PLC-beta4 function in signal processing within the retina, PLC-beta3 plays a role in the early development | Mus musculus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.4.11 | ? | x * 91000 | Dictyostelium discoideum |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.11 | NorpA | Drosophila sp. PLC-beta homolog | Drosophila sp. (in: flies) |
3.1.4.11 | PLC-21 | Drosophila sp. PLC-beta homolog | Drosophila sp. (in: flies) |