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Literature summary extracted from

  • Rebecchi, M.J.; Pentyala, S.N.
    Structure, function, and control of phosphoinositide-specific phospholipase C (2000), Physiol. Rev., 80, 1291-1335.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.11 G protein betagamma may be the main positive regulator of DdPLC Dictyostelium discoideum

Application

EC Number Application Comment Organism
3.1.4.11 medicine PLC-gamma1 may permit the progression of some tumors Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.11 C1094S NorpA mutant with slowed activation and deactivation Drosophila sp. (in: flies)
3.1.4.11 additional information DdPLC null mutant fails to aggregate at low cell densities Dictyostelium discoideum
3.1.4.11 additional information flies lacking NorpA are blind Drosophila sp. (in: flies)
3.1.4.11 additional information mutant mice lacking PLC-beta1: sudden death due to epileptic-like seizures, mutant mice lacking PLC-beta2 and PLC-beta4: phenotypes, homozygous disruption of the PLC-beta3 gene is lethal by day 2.5 of development, mutant mice with disruption of one or both copies of the PLC-gamma1 gene, homozygous mice die by embryonic day 9 Mus musculus
3.1.4.11 additional information PLC1 deletion mutant with slowed growth Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.11 Ca2+ Ca2+-dependent Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.11 91000
-
x * 91000 Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.11 additional information Arabidopsis thaliana AtPLC1S is involved in stress responses, AtPLC2 not ?
-
?
3.1.4.11 additional information Rattus norvegicus cellular signaling ?
-
?
3.1.4.11 additional information Homo sapiens cellular signaling, regulation of PLC activity ?
-
?
3.1.4.11 additional information Drosophila sp. (in: flies) PLC plays a key role in photoreceptor response ?
-
?
3.1.4.11 additional information Mus musculus PLC-beta1 is nessecary for the development and/or maintenance of brain inhibitory pathways, the retinal variants of PLC-beta4 function in signal processing within the retina, PLC-beta3 plays a role in the early development ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Arabidopsis thaliana
-
AtPLC1S, AtPLC2, delta-related isotypes
-
3.1.4.11 Dictyostelium discoideum
-
DdPLC, homolog to mammalian PLC-delta
-
3.1.4.11 Drosophila sp. (in: flies)
-
NorpA, PLC-21
-
3.1.4.11 Homo sapiens
-
-
-
3.1.4.11 Mus musculus
-
PLC-beta
-
3.1.4.11 Rattus norvegicus
-
-
-
3.1.4.11 Saccharomyces cerevisiae
-
PLC1p
-
3.1.4.11 Saccharomyces cerevisiae PLC1p
-
PLC1p
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.11 phosphoprotein PLC-gamma1, phosphorylation sites: Tyr-771 and Tyr-783 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 astrocyte adult brain, PLC-delta1 is concentrated in astroglial cells, much lower levels in neurons Rattus norvegicus
-
3.1.4.11 brain adult, PLC-gamma1 is diffusely distributed, expression pattern of PLC-gamma1 and PLC-delta1 during development, expression pattern of PLC-gamma2 Rattus norvegicus
-
3.1.4.11 embryo high PLC-beta3 expression in very early embryos Mus musculus
-
3.1.4.11 embryo PLC-gamma homolog, widely distributed in the embryo Drosophila sp. (in: flies)
-
3.1.4.11 eye NorpA type I, eye-specific Drosophila sp. (in: flies)
-
3.1.4.11 flower constitutive expression of AtPLC2 in vegetative and floral tissues Arabidopsis thaliana
-
3.1.4.11 head PLC-21 type I, head-specific Drosophila sp. (in: flies)
-
3.1.4.11 hippocampus PLC-beta1 is prominently expressed in hippocampal pyramidal cells Mus musculus
-
3.1.4.11 leaf AtPLC1S is concentrated in shoot and leaf Arabidopsis thaliana
-
3.1.4.11 additional information PLC-beta2 is highly expressed in cells of the immune system Mus musculus
-
3.1.4.11 neuron adult brain, much lower levels of PLC-delta1 in neurons than in astroglial cells Rattus norvegicus
-
3.1.4.11 oocyte high PLC-beta3 expression in unfertilized oocytes Mus musculus
-
3.1.4.11 retina PLC-beta4 Mus musculus
-
3.1.4.11 shoot AtPLC1S is concentrated in shoot and leaf Arabidopsis thaliana
-
3.1.4.11 vegetative cell constitutive expression of AtPLC2 in vegetative and floral tissues Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Drosophila sp. (in: flies) 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Arabidopsis thaliana 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Dictyostelium discoideum 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O preferred substrate Saccharomyces cerevisiae 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structures of PLC-beta, -gamma and -delta isoenzymes Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structures of PLC–beta, -gamma and -delta isoenzymes Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O preferred substrate Saccharomyces cerevisiae PLC1p 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
3.1.4.11 additional information AtPLC1S is involved in stress responses, AtPLC2 not Arabidopsis thaliana ?
-
?
3.1.4.11 additional information cellular signaling Rattus norvegicus ?
-
?
3.1.4.11 additional information cellular signaling, regulation of PLC activity Homo sapiens ?
-
?
3.1.4.11 additional information PLC plays a key role in photoreceptor response Drosophila sp. (in: flies) ?
-
?
3.1.4.11 additional information PLC-beta1 is nessecary for the development and/or maintenance of brain inhibitory pathways, the retinal variants of PLC-beta4 function in signal processing within the retina, PLC-beta3 plays a role in the early development Mus musculus ?
-
?

Subunits

EC Number Subunits Comment Organism
3.1.4.11 ? x * 91000 Dictyostelium discoideum

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 NorpA Drosophila sp. PLC-beta homolog Drosophila sp. (in: flies)
3.1.4.11 PLC-21 Drosophila sp. PLC-beta homolog Drosophila sp. (in: flies)