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Literature summary extracted from

  • Suopanki, J.; Tyynela, J.; Baumann, M.; Haltia, M.
    Palmitoyl-protein thioesterase, an enzyme implicated in neurodegeneration, is localized in neurons and is developmentally regulated in rat brain (1999), Neurosci. Lett., 265, 53-56.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.22 lysosome
-
 Rattus norvegicus 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.22 additional information Rattus norvegicus the enzyme is essential for both development and maintenance of cortical neurons, enzyme deficiency causes severe neurodegenerative disorders by loss of cortical neurons ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.22 Rattus norvegicus
-
 gene ppt
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.2.22 palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.22 brain expression of enzyme is developmentally regulated, with increasing expression during maturation of the CNS, reaching the maximum in young adulthood Rattus norvegicus
-
3.1.2.22 cerebrum
-
 Rattus norvegicus
-
3.1.2.22 embryo
-
 Rattus norvegicus
-
3.1.2.22 eye
-
 Rattus norvegicus
-
3.1.2.22 liver enzyme expression slowly decreases during maturation Rattus norvegicus
-
3.1.2.22 neuroepithelium
-
 Rattus norvegicus
-
3.1.2.22 neuron
-
 Rattus norvegicus
-
3.1.2.22 spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.22 additional information the enzyme is essential for both development and maintenance of cortical neurons, enzyme deficiency causes severe neurodegenerative disorders by loss of cortical neurons Rattus norvegicus ?
-
 ?
3.1.2.22 palmitoyl-[protein] + H2O hydrolysis of long-chain fatty acids from S-acylated proteins and CoA Rattus norvegicus palmitate + protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.22 Palmitoyl-protein thioesterase
-
 Rattus norvegicus