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Literature summary extracted from

  • Strosznajder, R.P.; Pokorski, M.
    Regulation of phospholipase C activity by calcium ions and guanine nucleotide in the normoxic cat carotid body (2000), Neurochem. Res., 25, 739-743.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.3 Ca2+ required, isoform acting on inositol-phosphatidylinositol Felis catus
3.1.4.3 GTPgammaS isoform acting on inositol-phosphatidylinositol-4,5-bisphosphate Felis catus
3.1.4.11 Ca2+ the enzyme acting on PtdIns is Ca2+-dependent, in contrary to that acting on PtdIns(4,5)P2 which remains active in the presence of 10 mM EGTA Felis catus
3.1.4.11 Carbachol small stimulatory effect of about 30% on the enzyme acting on PtdIns(4,5)P2. GTPgammaS enhances this effect Felis catus
3.1.4.11 dopamine small stimulatory effect of about 30% on the enzyme acting on PtdIns(4,5)P2. GTPgammaS enhances this effect Felis catus
3.1.4.11 GTPgammaS PtdIns(4,5)P2-PLC is stimulated by GTPgammaS. Enzyme acting on PtdIns is not activated by GTPgS Felis catus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.3 EDTA isoform acting on inositol-phosphatidylinositol Felis catus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.11 additional information Felis catus the enzymes acting against [3H] inositol-phosphatidylinositol (PtdIns) and [3H] inositolphosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] in the cat carotid bodies (CB) are investigated using labelled phospholipids as a source of the substrate. Analysis of water soluble inositol metabolites indicates that PtdIns is degraded exclusively by the enzyme since the inositolmonophosphate (IP1) is detected as a single product. In case of PtdIns(4,5)P2 hydrolysis by carotid bodies (CB) enzymes there are all 3 inositol phosphates: IP3, IP2, IP1 ?
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?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.3 Felis catus
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two isozymes
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3.1.4.11 Felis catus
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adult
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.3 carotid body
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Felis catus
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3.1.4.11 carotid body the carotid bodies (CB) are a paired chemoreceptor organ located at the bifurcation of the common carotid arteries Felis catus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.3 phosphatidylinositol + H2O Ca2+-dependent activity Felis catus inositol monophosphate + diacylglycerol
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?
3.1.4.3 phosphatidylinositol 4,5-bisphosphate + H2O Ca2+-independent activity Felis catus inositol 4,5-bisphosphate + phosphatidate
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?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
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Felis catus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
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?
3.1.4.11 additional information the enzymes acting against [3H] inositol-phosphatidylinositol (PtdIns) and [3H] inositolphosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] in the cat carotid bodies (CB) are investigated using labelled phospholipids as a source of the substrate. Analysis of water soluble inositol metabolites indicates that PtdIns is degraded exclusively by the enzyme since the inositolmonophosphate (IP1) is detected as a single product. In case of PtdIns(4,5)P2 hydrolysis by carotid bodies (CB) enzymes there are all 3 inositol phosphates: IP3, IP2, IP1 Felis catus ?
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?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 PtdIns(4,5)P2-PLC
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Felis catus