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Literature summary extracted from

  • Suopanki, J.; Lintunen, M.; Lahtinen, H.; Haltia, M.; Panula, P.; Baumann, M.; Tyynela, J.
    Status epilepticus induces changes in the expression and localization of endogenous palmitoyl-protein thioesterase 1 (2002), Neurobiol. Dis., 10, 247-257.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.22 additional information colocalization of the enzyme with the synaptic membrane marker is enhanced after epileptic seizures Rattus norvegicus
-
-
3.1.2.22 synapse cortical, in synaptic junctions of epileptic rats, nearly not in non-epileptic ones Rattus norvegicus 45202
-
3.1.2.22 synaptic vesicle
-
 Rattus norvegicus 8021
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.22 additional information Rattus norvegicus epileptic seizures in adult rats lead to progressive and remarkable increase in enzyme activity inlimbic areas of the brain, the enzyme may protect neurons from excitotoxicity and have a role in synaptic plasticity, enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.22 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.2.22 glycoprotein
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.2.22 palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.22 brain
-
 Rattus norvegicus
-
3.1.2.22 hippocampus
-
 Rattus norvegicus
-
3.1.2.22 neuron pyramidal Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.22 additional information epileptic seizures in adult rats lead to progressive and remarkable increase in enzyme activity inlimbic areas of the brain, the enzyme may protect neurons from excitotoxicity and have a role in synaptic plasticity, enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL Rattus norvegicus ?
-
 ?
3.1.2.22 palmitoyl-[protein] + H2O
-
 Rattus norvegicus palmitate + protein
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.2.22 ? x * 35000-37000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
3.1.2.22 palmitoyl-protein thioesterase 1
-
 Rattus norvegicus
3.1.2.22 PPT1
-
 Rattus norvegicus