Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Richards, P.G.; Johnson, M.K.; Ray, D.E.
    Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs (2000), Mol. Pharmacol., 58, 577-583.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.1 chlorfenvinphos IC50 at pH 7.4, 37°C: 1386 nM Sus scrofa
3.4.19.1 chlorpyrifos-methyl oxon IC50 at pH 7.4, 37°C: 18.3 nM Sus scrofa
3.4.19.1 DFP IC50 at pH 7.4, 37°C: 22.5 nM Sus scrofa
3.4.19.1 diazoxon IC50 at pH 7.4, 37°C: 1386 nM Sus scrofa
3.4.19.1 dichlorvos IC50 at pH 7.4, 37°C: 118.6 nM Sus scrofa
3.4.19.1 malaoxon IC50 at pH 7.4, 37°C: 1400000 nM Sus scrofa
3.4.19.1 Mipafox IC50 at pH 7.4, 37°C: 3013 nM Sus scrofa
3.4.19.1 paraoxon IC50 at pH 7.4, 37°C: 3805 nM Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.19.1 cytosol
-
 Sus scrofa 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.19.1 additional information Sus scrofa the enzyme may be involved in regulation of neuropeptide turnover ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.1 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.19.1
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.1 brain
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.1 additional information the enzyme may be involved in regulation of neuropeptide turnover Sus scrofa ?
-
 ?
3.4.19.1 N-acetyl-Ala-p-nitroanilide + H2O
-
 Sus scrofa N-acetyl-Ala + p-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.19.1 acylpeptide hydrolase
-
 Sus scrofa
3.4.19.1 OP85
-
 Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.19.1 0.0000183
-
 IC50 at pH 7.4, 37°C: 18.3 nM Sus scrofa chlorpyrifos-methyl oxon
3.4.19.1 0.0000225
-
 IC50 at pH 7.4, 37°C: 22.5 nM Sus scrofa DFP
3.4.19.1 0.0001186
-
 IC50 at pH 7.4, 37°C: 118.6 nM Sus scrofa dichlorvos
3.4.19.1 0.001386
-
 IC50 at pH 7.4, 37°C: 1386 nM Sus scrofa diazoxon
3.4.19.1 0.001386
-
 IC50 at pH 7.4, 37°C: 1386 nM Sus scrofa chlorfenvinphos
3.4.19.1 0.003013
-
 IC50 at pH 7.4, 37°C: 3013 nM Sus scrofa Mipafox
3.4.19.1 0.003805
-
 IC50 at pH 7.4, 37°C: 3805 nM Sus scrofa paraoxon
3.4.19.1 1.4
-
 IC50 at pH 7.4, 37°C: 1400000 nM Sus scrofa malaoxon