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Literature summary extracted from

  • Munoz, R.; Lopez, R.; De Frutos, M.; Garcia, E.
    First molecular characterization of a uridine diphosphate galacturonate 4-epimerase: an enzyme required for capsular biosynthesis in Streptococcus pneumoniae type 1 (1999), Mol. Microbiol., 31, 703-713.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.1.3.6 overexpression in Escherichia coli Streptococcus pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.1.3.6 CDP-glucose
-
Streptococcus pneumoniae
5.1.3.6 galactose
-
Streptococcus pneumoniae
5.1.3.6 GDP-glucose
-
Streptococcus pneumoniae
5.1.3.6 GMP
-
Streptococcus pneumoniae
5.1.3.6 NaCl progressive decrease in activity above 100 mM NaCl, activity drops below 50% at 250 mM Streptococcus pneumoniae
5.1.3.6 p-hydroxymercuribenzoate reactivation by NAD+ and 2-mercaptoethanol Streptococcus pneumoniae
5.1.3.6 UDP
-
Streptococcus pneumoniae
5.1.3.6 UDP-galactose
-
Streptococcus pneumoniae
5.1.3.6 UDP-glucose
-
Streptococcus pneumoniae
5.1.3.6 UDP-mannose
-
Streptococcus pneumoniae
5.1.3.6 UDP-xylose
-
Streptococcus pneumoniae
5.1.3.6 UMP
-
Streptococcus pneumoniae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.1.3.6 0.24
-
UDP-D-glucuronate pH 7.5, 37°C Streptococcus pneumoniae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.1.3.6 40000
-
2 * 40000, SDS-PAGE Streptococcus pneumoniae
5.1.3.6 80000
-
gel filtration Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.6 additional information Streptococcus pneumoniae the enzyme is required for capsular biosynthesis ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.6 Streptococcus pneumoniae
-
type 1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.1.3.6
-
Streptococcus pneumoniae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.6 additional information the enzyme is required for capsular biosynthesis Streptococcus pneumoniae ?
-
?
5.1.3.6 UDP-D-glucuronate equilibrium constant in direction of UDP-galacturonate formation is 1.3 Streptococcus pneumoniae UDP-D-galacturonate
-
r

Subunits

EC Number Subunits Comment Organism
5.1.3.6 dimer 2 * 40000, SDS-PAGE Streptococcus pneumoniae

Synonyms

EC Number Synonyms Comment Organism
5.1.3.6 UDPGLE
-
Streptococcus pneumoniae
5.1.3.6 uridine diphosphate galacturonate 4-epimerase
-
Streptococcus pneumoniae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.1.3.6 37 42
-
Streptococcus pneumoniae

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
5.1.3.6 25
-
60 min, about 35% loss of activity Streptococcus pneumoniae
5.1.3.6 30
-
60 min, about 50% loss of activity Streptococcus pneumoniae
5.1.3.6 37
-
60 min, about 75% loss of activity Streptococcus pneumoniae
5.1.3.6 42
-
60 min, about 20% loss of activity Streptococcus pneumoniae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.1.3.6 7.5
-
-
Streptococcus pneumoniae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
5.1.3.6 6.5 10 pH 6.5: about 50% of maximal activity, pH 10.0: about 25% of maximal activity Streptococcus pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
5.1.3.6 NAD+ 50 nM to 5 mM, does not affect activity Streptococcus pneumoniae