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Literature summary extracted from
- Degradation by proteases Lon, Clp and HtrA, of Escherichia coli proteins aggregated in vivo by heat shock; HtrA protease action in vivo and in vitro (1996), Mol. Microbiol., 22, 555-571.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.107 | DnaJ | chaperone protein | Escherichia coli |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.107 | Mg2+ | stimulates at 10 mM | Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | additional information | Escherichia coli | involved in the degradation of damaged proteins, participate in removal of aggregated proteins | ? | - |
? | |
| 3.4.21.107 | Protein + H2O | Escherichia coli | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.107 | Escherichia coli | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.107 | wild-type, htrA22 and htrA63 mutant | Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | beta-casein + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.4.21.107 | additional information | involved in the degradation of damaged proteins, participate in removal of aggregated proteins | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | Protein + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.4.21.107 | Protein + H2O | denatured proteins aggregate to form a distinct S fraction, one third of the isolated S fraction is converted to trichloroacetic acid-soluble products | Escherichia coli | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | DegP | - |
Escherichia coli |
| 3.4.21.107 | Do | - |
Escherichia coli |
| 3.4.21.107 | HtrA | - |
Escherichia coli |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.107 | 37 | 45 | enzyme is more efficient at 45°C than at 37°C | Escherichia coli |
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