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Literature summary extracted from

  • Suopanki, J.; Tyynela, J.; Baumann, M.; Haltia, M.
    The expression of palmitoyl-protein thioesterase is developmentally regulated in neural tissues but not in nonneural tissues (1999), Mol. Genet. Metab., 66, 290-293.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.22 additional information Rattus norvegicus enzyme deficiency causes infantile neuronal ceroid lipofuscinosis, the enzyme plays an important role in the development of the CNS ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.22 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.2.22 palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.22 brain
-
 Rattus norvegicus
-
3.1.2.22 cerebellum
-
 Rattus norvegicus
-
3.1.2.22 cerebrum
-
 Rattus norvegicus
-
3.1.2.22 eye
-
 Rattus norvegicus
-
3.1.2.22 additional information the enzyme expression is strictly developmentally regulated in brain and eyes but not in spleen Rattus norvegicus
-
3.1.2.22 neuron
-
 Rattus norvegicus
-
3.1.2.22 retina
-
 Rattus norvegicus
-
3.1.2.22 spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.22 additional information enzyme deficiency causes infantile neuronal ceroid lipofuscinosis, the enzyme plays an important role in the development of the CNS Rattus norvegicus ?
-
 ?
3.1.2.22 palmitoyl-[protein] + H2O hydrolysis of long-chain fatty acids from S-acylated proteins and CoA Rattus norvegicus palmitate + protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.22 Palmitoyl-protein thioesterase
-
 Rattus norvegicus
3.1.2.22 PPT
-
 Rattus norvegicus