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Literature summary extracted from

  • Cao, Y.; Zhao, Z.; Gruszczynska-Biegala, J.; Zolkiewska, A.
    Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro (2003), Mol. Cell. Biol., 23, 6725-6738.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B10 overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B10 L73P mutant with properties similar to wild-type concerning the cell cycle of C2C12 cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B10 small interfering RNA inhibits expression of the enzyme in C2C12 cells Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B10 additional information metalloprotease domain is not essential for inhibition of cell cycle progression by the enzyme Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B10 additional information Mus musculus overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation ?
-
?
3.4.24.B10 protein + H2O Mus musculus
-
peptides
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B10 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B10 proteolytic modification
-
Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B10 C2C12 cell myoblast cell line Mus musculus
-
3.4.24.B10 myoblast cell culture, reserve cells, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts Mus musculus
-
3.4.24.B10 myotube low content in the multinucleated cells Mus musculus
-
3.4.24.B10 skeletal muscle myoblast Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B10 additional information overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation Mus musculus ?
-
?
3.4.24.B10 protein + H2O
-
Mus musculus peptides
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B10 a disintegrin and metalloprotease-12
-
Mus musculus
3.4.24.B10 ADAM12
-
Mus musculus
3.4.24.B10 M12.212 Merops-ID Mus musculus
3.4.24.B10 metalloprotease-disintegrin ADAM12
-
Mus musculus