EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.B10 | overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.24.B10 | L73P | mutant with properties similar to wild-type concerning the cell cycle of C2C12 cells | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B10 | small interfering RNA | inhibits expression of the enzyme in C2C12 cells | Mus musculus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B10 | additional information | metalloprotease domain is not essential for inhibition of cell cycle progression by the enzyme | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B10 | additional information | Mus musculus | overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation | ? | - |
? | |
3.4.24.B10 | protein + H2O | Mus musculus | - |
peptides | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.B10 | Mus musculus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.24.B10 | proteolytic modification | - |
Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.B10 | C2C12 cell | myoblast cell line | Mus musculus | - |
3.4.24.B10 | myoblast | cell culture, reserve cells, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts | Mus musculus | - |
3.4.24.B10 | myotube | low content in the multinucleated cells | Mus musculus | - |
3.4.24.B10 | skeletal muscle | myoblast | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B10 | additional information | overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation | Mus musculus | ? | - |
? | |
3.4.24.B10 | protein + H2O | - |
Mus musculus | peptides | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.B10 | a disintegrin and metalloprotease-12 | - |
Mus musculus |
3.4.24.B10 | ADAM12 | - |
Mus musculus |
3.4.24.B10 | M12.212 | Merops-ID | Mus musculus |
3.4.24.B10 | metalloprotease-disintegrin ADAM12 | - |
Mus musculus |